Primary Multidrug-Resistant Mycobacterium tuberculosis in 2 Regions,Eastern Siberia,Russian Federation |
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| Authors: | Svetlana Zhdanova Scott K. Heysell Oleg Ogarkov Galina Boyarinova Galina Alexeeva Suporn Pholwat Elena Zorkaltseva Eric R. Houpt Eugeniy Savilov |
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| Affiliation: | Russian Academy of Medical Sciences, Irkutsk, Russian Federation (S. Zhdanova, O. Ogarkov, E. Savilov); ;University of Virginia, Charlottesville, Virginia, USA (S.K. Heysell, G. Boyarinova, S. Pholwat, E.R. Houpt); ;Regional TB-Prevention Dispensary, Irkutsk (O. Ogarkov, E. Zorkaltseva); ;Research Practice Center for Phthisiatry, Yakutsk, Russian Federation (G. Alexeeva); ;State Medical Continuing Education Academy, Irkutsk (E. Zorkaltseva, E. Savilov) |
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| Abstract: | Of 235 Mycobacterium tuberculosis isolates from patients who had not received tuberculosis treatment in the Irkutsk oblast and the Sakha Republic (Yakutia), eastern Siberia, 61 (26%) were multidrug resistant. A novel strain, S 256, clustered among these isolates and carried eis-related kanamycin resistance, indicating a need for locally informed diagnosis and treatment strategies. |
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| Keywords: | tuberculosis multidrug-resistant tuberculosis MDR TB HIV Siberia Russian Federation genotype mycobacterial interspersed repetitive unit MIRU-VNTR pncA pyrazinamide tuberculosis and other mycobacteria |
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