Metastasis of lung adenosquamous carcinoma to meningioma: case report with literature review |
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Authors: | Ryan Glass Supriya R Hukku Bruce Gershenhorn Juan Alzate Bradford Tan |
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Affiliation: | 1.Department of Radiation Biology, Memorial Sloan Kettering Cancer Center, New York, NY;2.Department of Pathology, Cancer Treatment Centers of America at Midwestern Regional Medical Center, Zion, IL, USA;3.Department of Oncology, Cancer Treatment Centers of America, Zion, IL, USA;4.Department of Neurosurgery, Cancer Treatment Centers of America, Zion, IL, USA |
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Abstract: | The occurrence of metastasis of a systemic neoplasm to an intracranial tumor is a rare phenomenon. Meningiomas have been reported as the most common intracranial tumor to harbor a systemic metastasis, with breast and lung carcinomas being the most common sites of origination. Here, we report a case of an adenocarcinoma metastasis of an adenosquamous lung carcinoma found within a meningioma, resulting in the patient’s first clinical manifestations. We also review the literature for other cases of adenocarcinoma metastatic to a meningioma and suggest mechanisms that make meningiomas likely to harbor systemic metastases including increased vascularity, slow growth rate, increased hyaline content and expression of cell-cell adhesion molecules. |
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Keywords: | Tumor-to-tumor meningioma adenosquamous carcinoma |
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