三苯氧胺对绝经后乳腺癌患者子宫和卵巢的影响

目的：选择54例采用三苯氧胺（TAM）治疗的绝经期后乳腺癌患者进行研究，观察药物对子宫和卵巢的影响，以期制定相应对策，方法：采用妇科检查，盆腔B超，定期随访等，结果：服用TAM后，子宫内膜明显增厚，其中5例诊断为子宫内膜增生，3例子宫肌瘤，5例卵巢囊肿，结论：TAM具有导致子宫内膜病变，促进子宫肌瘤的发生和发展，诱发卵巢囊肿等副作用，停药后，单纯性卵巢囊肿可以自行消失，子宫内膜增厚可逐渐恢复，因此应该对长期服用TAM的患者进行密切观察，正确治疗。

Influence of Tamoxifen on Uterus and Ovary in Postmenopausal Patients with Breast Cancer

Objective:In this prospecitve study 54 postmenopausal patients with breast cancer were adopted to evaluate the role of tamoxifen on uterus and ovary, aiming at its corresponding treatment. Methods:Gynecological examination, pelvic ultrasoungraph and follow-up were carried out. Results:After tamoxifen treatment uterine pathological examination indicated 5 patients of endometrial hyperlasia and 3 cases with uterine leiomyoma. Meanwhile there were five patients with ovarian cyst. Conclusion:Long-term tamoxifen therapy may result in endomtrial pathologies, ovarian cyst and uterine leiomyoma. Most of simple ovarial cysts are reversible and some of uterine pathological change can be improved after stoping treatment of tamoxifen. The patients with tamoxifen treatment must be closely followed and the tamoxifen side-effects on uterus and ovary should be concerned.