| 新型关节炎注射液-羧甲基壳聚糖的研究 |
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| 引用本文： | 胡巧玲,张中明,章鸣,高根德.新型关节炎注射液-羧甲基壳聚糖的研究[J].生物医学工程学杂志,2004,21(1):25-27. |
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| 作者姓名： | 胡巧玲 张中明 章鸣 高根德 |
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| 作者单位： | 1. 浙江大学,高分子复合材料研究所,杭州,310027
2. 浙江省中医学院,骨伤科,杭州,310009 |
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| 基金项目： | 国家自然科学基金资助项目 ( 5 0 173 0 2 3 ) |
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| 摘 要： | 利用壳聚糖分子 C6 位上羟基与氯乙酸反应制得了水溶性羧甲基壳聚糖 (O- CMC) ,电导法测定羧甲基的取代度为 0 .76。对其进行了溶解性表征及动物造模试验。试验结果表明 O- CMC具有润滑关节 ,有效抑制兔膝关节内成纤维细胞增殖的作用 ,有利于病理性关节软骨的修复 ,对兔类风湿性关节炎有较好的疗效
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| 关 键 词： | 羧甲基壳聚糖 关节炎 滑膜细胞 |
Study on a New Antarthritic Injection-O-carboxymethyl Chitosan |
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| Hu Qiaoling,Zhang Zhongming,Zhang Ming,Gao Gende.Study on a New Antarthritic Injection-O-carboxymethyl Chitosan[J].Journal of Biomedical Engineering,2004,21(1):25-27. |
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| Authors: | Hu Qiaoling Zhang Zhongming Zhang Ming Gao Gende |
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| Institution: | Institute of Polymer Composites, Zhejiang University, Hangzhou 310027, China. |
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| Abstract: | A type of water-soluble carboxymethyl chitosan(O-CMC), with 76% degree of substitution determined by conductivity method,was prepared by using chloroacetic acid to react with C 6-OH of chitosan. The solubility of O-CMC was characterized also. Animal experiment in rabbits showed that O-CMC could lubricate arthron, inhibit proliferation of fibroblast cells on rabbits' knee joints, benefit the process of repairing pathologic articular cartilage, and produce good therapeutic effect on rheumatoid arthritis. |
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| Keywords: | O-carboxymethyl chitosan Arthritis Synovial cell |
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