| 免疫抑制治疗56例儿童获得性重型再生障碍性贫血的转归 |
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| 引用本文： | 王书春,陈晓娟,邹尧,杨文钰,刘天峰,张丽,陈玉梅,郭晔,竺晓凡.免疫抑制治疗56例儿童获得性重型再生障碍性贫血的转归[J].中华儿科杂志,2009,47(8):613-616. |
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| 作者姓名： | 王书春 陈晓娟 邹尧 杨文钰 刘天峰 张丽 陈玉梅 郭晔 竺晓凡 |
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| 作者单位： | 中国医学科学院血液学研究所血液病医院儿科,天津,300020 |
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| 摘 要： | Objective To investigate prognostic factors of immunosuppressive therapy (IST) in children acquired severe aplastic anemia(SAA). Methods Data of 56 consecutive children cases with SAA who had received rabbit anti-thymocyte globulin (R-ATG) 3-5 mg/(kg·d)×5 d] and cyclosporine A (CSA) from January 2000 to June 2006 were retrospectively analyzed. No repeated courses of R-ATG were given for nortresponders. All the patients also received stanozolol or testosterone propionate. The dose of CSA was adjusted to maintain trough drug levels above 100 μg/L and peak drug levels above 300 μg/L. Results The overall response rate to the immtmosuppressive therapy (IST) was 62.5% and the complete remission rate was 37.5%. The 5-year overall survival for IST regimens was 66.27%±6.84%, patients who had infections when using ATG had significandy lower response and higher mortality. Patients whose nucleated erythrocyte population in bone marrow was ≥ 10% had good prognosis. Patients whose granulocytes population in bone marrow was ≥10% had lower mortality. Conclusion Patients who had infections when using ATG had significantly lower response and higher mortality. Patients whose nucleated erythrocyte population in bone marrow was ≥10% had good prognosis.
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| 关 键 词： | 贫血 再生障碍性 儿童 免疫抑制法 预后 |
Prognostic factors of immunosuppresive therapy in children aquired aplastic anemia |
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| WANG Shu-chun,CHEN Xiao-juan,ZOU Yao,YANG Wen-yu,LIU Tian-feng,ZHANG Li,CHEN Yu-mei,GUO Ye,ZHU Xiao-fan.Prognostic factors of immunosuppresive therapy in children aquired aplastic anemia[J].Chinese Journal of Pediatrics,2009,47(8):613-616. |
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| Authors: | WANG Shu-chun CHEN Xiao-juan ZOU Yao YANG Wen-yu LIU Tian-feng ZHANG Li CHEN Yu-mei GUO Ye ZHU Xiao-fan |
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| Abstract: | Objective To investigate prognostic factors of immunosuppressive therapy (IST) in children acquired severe aplastic anemia(SAA). Methods Data of 56 consecutive children cases with SAA who had received rabbit anti-thymocyte globulin (R-ATG) 3-5 mg/(kg·d)×5 d] and cyclosporine A (CSA) from January 2000 to June 2006 were retrospectively analyzed. No repeated courses of R-ATG were given for nortresponders. All the patients also received stanozolol or testosterone propionate. The dose of CSA was adjusted to maintain trough drug levels above 100 μg/L and peak drug levels above 300 μg/L. Results The overall response rate to the immtmosuppressive therapy (IST) was 62.5% and the complete remission rate was 37.5%. The 5-year overall survival for IST regimens was 66.27%±6.84%, patients who had infections when using ATG had significandy lower response and higher mortality. Patients whose nucleated erythrocyte population in bone marrow was ≥ 10% had good prognosis. Patients whose granulocytes population in bone marrow was ≥10% had lower mortality. Conclusion Patients who had infections when using ATG had significantly lower response and higher mortality. Patients whose nucleated erythrocyte population in bone marrow was ≥10% had good prognosis. |
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| Keywords: | AnemiaaplasdeChildImmunosuppressionPrognosis |
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