血清超敏C反应蛋白与低密度脂蛋白胆固醇联合检测在2型糖尿病大血管病变中的

目的 探讨2型糖尿病大血管并发症患者血清超敏C反应蛋白（hs-CRP）与低密度脂蛋白胆固醇（LDL-C）水平的变化及其临床意义.方法 检测200例有或无大血管并发症的2型糖尿病患者及40例健康人的血清hs-CRP、总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、LDL-C浓度.结果 2型糖尿病患者无论有无大血管并发症,其hs-CRP、TC、TG、LDL-C水平均明显高于正常对照组（P＜0.05）,大血管并发症组hs-CRP、LDL-C水平明显高于无大血管并发症组（P＜0.05）.大血管并发症组血清hs-CRP水平与LDL-C水平呈明显正相关（r=0.47,P＜0.05）.结论 hs-CRP及LDL-C可作为2型糖尿病并发大血管病变危险性的重要实验室指标.两者联合检测对2型糖尿病并发大血管病变的预测及早期诊断有重要的临床价值.

Clinical significance of combinative detection of serum hs-CRP and LDL-C in type 2 diabetes with vascular complications

Objective To explore the change and clinic significance of serum sensitive c-reactive protein （hs-CRP） and LDL-C levels in type 2 diabetes with vascular complications. Methods The levels of hs-CRP,TC, TG, HDL-C, LDL-C were detected on two hundred diabetes patients with/without vascular complications and forty healthy subjects. Results Compared with those of control group, the eoneent rations of CRP,TC,TG and LDL-C were higher significantly in diabetes gruup（P 〈0.05） ;the levels of hsCRP and LDL-C in diabetes with vascular complications were higher than those of without complications（ P 〈0.05 ） ;the pattern of hs-CRP and LDL-C expression in diabetes with vascular complications showed astatistically significant correlation （ r =- 0. 47, P 〈 0.05 ）. Conclusions The levels of serum hs-CRP and LDL-C can be used as the indexes for predict the risk of type 2 diabetes with vascular complications, the Combinative detection of them is Benefit to the prediction and early diagnosis of type 2 diabetes with vas- cular complications.