稳定期慢性阻塞性肺疾病患者的工作记忆缺陷

目的探讨稳定期慢性阻塞性肺疾病(Chronic obstructive pulmonary disease,COPD)患者和健康对照被试(healthcontrols,HC)之间工作记忆的差异。方法对30例稳定期COPD患者及与其人口学资料相匹配的30名HC被试进行空间、客体及语音工作记忆,比较两组正确率及反应时间的差异。结果 COPD组在空间工作记忆,客体工作记忆的正确率低于HC组[分别为:(88±12)%vs(93±5)%;(64±8)%vs(69±10)%],差异有统计学意义(分别为t=-2.442,P=0.018;t=-2.471,P=0.019);COPD组在空间、客体、语音工作记忆的反应时均低于HC组[分别为:(1333.72±226.34)ms vs(1015.50±181.98)ms;(1521.14±290.57)ms vs(1322.54±350.21)ms;(1392.68±246.08)ms vs(1123.56±328.84)ms],差异有统计学意义[分别为t=6.001,P=0.000;t=2.390,P=0.020;t=3.589,P=0.001]。COPD患者PaCO2值与空间工作记忆反应时具有显著负相关(r=-0.374,P=0.042)。结论 COPD患者工作记忆损伤并不均衡,可能是缺氧对患者中枢系统不同脑区损伤有关。

Working memory impairment in patients with chronic obstructive pulmonary disease at stable stage

Objective To investigate the differences of working memory performance between patients with chronic obstructive pulmonary disease（COPD） at stable stage and health controls（HC）.Methods 30 COPD patients at stable stage and 30 healthy people were selected in this study,and they were given the working memory tests about space,object,verbal.Then the accurate rate and reaction time were compared between the two groups.Results The accurate rate of the object and space working memory was worse in the COPD group than in the HC group [（88 ± 12） % vs（93 ± 5） %;（64 ± 8） % vs（69 ± 10） % respectively]（t =-2.442,P = 0.018;t = 2.471,P = 0.019 respectively）.The reaction time about space,object,and verbal was obviously shorter in the control group than in the COPD group [（1333.72 ± 226.34） ms vs（1015.50 ± 181.98） ms;（1521.14 ± 290.57） ms vs（1322.54 ± 350.21） ms;（1392.68 ± 246.08） ms vs（1123.56 ± 328.84） ms respectively]（t = 6.001,P = 0.000;t = 2.390,P = 0.020;t = 3.589,P = 0.001 respectively）.The study indicated the level of PaCO2 in COPD patients was negatively correlated to reaction time on space working memory test（r =-0.374,P = 0.042）.Conclusion The COPD patients show disproportion impairment on the space,verbal and object working memory,which is probably caused by hypoxia injures to the different encephalic region.