亚砷酸联合维甲酸治疗急性早幼粒细胞白血病的疗效和观察

目的探讨亚砷酸联合维甲酸治疗急性早幼粒细胞白血病的疗效。方法将45例急性早幼粒细胞性白血病患者随机分为双诱导组(亚砷酸联+维甲酸)、维甲酸组、常规化疗组,观察各组白细胞总数、早幼粒细胞、缓解时间和药物不良反应。结果双诱导组治疗1周后早幼粒细胞比率、白细胞总数、CR与维甲酸组、常规化疗组比较,差异有显著性(P<0.05)。结论亚砷酸联合维甲酸治疗急性早幼粒细胞白血病短期疗效显著,完全缓解率高。

Study on curative effect and adverse reactions of combination chemotherapy of all - tram retinoic acid and arsenic trioxide in treatment of patients with acute promyelocytic leukemia.

Objective To explore the curative effect and adverse reactions of combination chemotherapy of all - trans retinoic acid and arsenic trioxide in treatment of patients with acute promyelocytic leukemia. Methods Forty five patients with premyelocytic leukemia were randomly allocated into ATRA combined with ATO group, ATRA group and routine chemotherapy group. The duration of remission, ratio of progranulo-cytes, total amount of leukocytes and drug adverse reactions of patients in each group were observed. Results The ratio of progranulocytes, total amount of leukocytes and complete response （CR） in ATRA combined with ATO group compared with other groups, and their difference was significant （ P 〈 0.05 ）. Conclusion The short - term effect of combination chemotherapy with all - trans retinoie acid and arsenic trioxide in treatment of patients with acute promyelocytic leukemia is significant, and its rate of complete remission is high.