系统性红斑狼疮患者外周血T淋巴细胞亚群、免疫球蛋白及补体变化分析 |
| |
引用本文: | 孙家祥,李艳,刘利洪,鄂建飞.系统性红斑狼疮患者外周血T淋巴细胞亚群、免疫球蛋白及补体变化分析[J].临床和实验医学杂志,2013,12(9):654-655. |
| |
作者姓名: | 孙家祥 李艳 刘利洪 鄂建飞 |
| |
作者单位: | 孙家祥 (四川德阳市人民医院检验科 四川 德阳618000); 李艳 (四川德阳市人民医院检验科 四川 德阳618000); 刘利洪 (四川德阳市人民医院检验科 四川 德阳618000); 鄂建飞 (四川德阳市人民医院检验科 四川 德阳618000); |
| |
摘 要: | 【摘要】目的探讨T淋巴细胞亚群、免疫球蛋白及补体在系统性红斑狼疮(SLE)患者中的变化及临床意义。方法对55例SLE患者外周血CD3+、CD4+、CD8+T淋巴细胞、免疫球蛋白及补体进行检测分析,另选取50名健康体检者作为对照组。CD3+、CD4+、CD8+T淋巴细胞用流式细胞仪检测,免疫球蛋白及补体采用透射比浊法在全自动生化仪上检测。结果研究组外周血CD3+、CD4+、CD8+T淋巴细胞绝对值及CD4+/CD8+比值、C3、C4明显低于对照组,IgG、IgA、IgM明显高于对照组(P〈0.01)。结论SLE患者T淋巴细胞亚群、免疫球蛋白及补体水平变化明显,三者联合检测,有利于病情监测及指导治疗。
|
关 键 词: | 系统性红斑狼疮 T淋巴细胞亚群 免疫球蛋白 补体 |
Study on changes in peripheral blood T lymphocyte subsets, immunoglobulin and complement in SLE patients. |
| |
Institution: | SUN Jia -xiang, LI Yan, LIU Li - hong, et al. Department of Clinical Laboratory, The People's Hospital of Deyang, Deyang Sichuan 618000, China. |
| |
Abstract: | Objective To explore the changes and clinical significance of T lymphocyte subsets, immunoglobulin, and complements in patients with systemic lupus erythematosus (SLE). Methods The levels of peripheral blood CD3 + CD4 + and CDs + T lymphocytes, immunoglobulin and complements in 55 cases of SLE were detected and analyzed. Fifty healthy persons were allocated in control group. CD3, + CD4 + and CD8 + T lymphocytes were detected by flow cytometry, immunoglobulin and complements were detected with turbidimetrie method by automatic biochemical analyzer. Results In comparison with normal control group, the absolute number of CD3 + CD4 + and CDs + lymphocytes and CD4 + / CD8+ ratio, C3 and C4 in study group were significantly decreased ( P 〈 0.01 ) , blood levels of IgG, IgA and IgM were significantly increased ( P 〈 0.01 ). Conclusion The levels of T lymphocyte subsets, immunoglobulin and complements in patients with SLE were significantly changed. The joint detection of 3 markers has important clinical significance in comprehensive understanding of the immune status of host and correct evaluation of the Severity of disease, thus it may guide the clinical treatment. |
| |
Keywords: | Systemic lupus erythematosus T lymphocyte subsets immunoglobulin Complement |
本文献已被 维普 等数据库收录! |
|