High levels of Lp(a) lipoprotein in a family ith cases of severe pre-eclampsia |
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| Authors: | Henrik Husby,Borghild Roald,Rune Schjetlein,Britt-Igjerd Nesheim,Kå re Berg |
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| Affiliation: | Department of Obstetrics and Gynecology, Ullevål University Hospital, Oslo;Department of Pathology, Ullevål University Hospital, Oslo.;Hematological Research Laboratory, Ullevål University Hospital, Oslo;Institute of Medical Genetics, University of Oslo, Oslo;Department of Medical Genetics, Ullevål University Hospital, Oslo, Norway |
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| Abstract: | We report a family with two cases of severe pre-eclampsia/eclampsia in which very high levels of Lp(a) lipoprotein were found. The serum level of Lp(a) lipoprotein is genetically determined and the Lp(a) apolipoprotein has a close homology to plasminogen. Very high levels of Lp(a) lipoprotein might interfere with the fibrinolytic/thrombolytic process in man. A previous report suggested that a high maternal serum Lp(a) lipoprotein level can cause fetal growth retardation, and it is proposed that very high levels might lead to increased deposition of fibrin in the uterine spiral arteries in pregnancy, which is central in the pathogenesis of pre-eclampsia. If confirmed, a very high Lp(a) lipoprotein level could be one risk factor for pre-eclampsia that is genetically determined. |
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| Keywords: | Lp(a)yy placental insufficiency pre-eclampsia risk factors vascular disease |
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