| 153Sm-EDTMP治疗前列腺癌内分泌治疗后骨转移骨痛的效果评价 |
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| 引用本文： | 汤召兵,陈在贤,刘朝东,刘航,王德林.153Sm-EDTMP治疗前列腺癌内分泌治疗后骨转移骨痛的效果评价[J].重庆医科大学学报,2006,31(3):417-418,421. |
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| 作者姓名： | 汤召兵 陈在贤 刘朝东 刘航 王德林 |
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| 作者单位： | 重庆医科大学附属第一医院泌尿外科,重庆,400016 |
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| 摘 要： | 目的:评价153Sm-EDTMP(153钐-乙二胺四甲撑膦酸)对前列腺癌患者行内分泌治疗后骨转移灶骨痛的治疗效果.方法:选择18例前列腺癌已行双侧睾丸切除术+口服福至尔治疗3～6个月、骨转移灶及骨痛未缓解患者,用153Sm-EDTMP治疗,153Sm-EDTMP用量为37MBq/kg体重·次,1次/月×(3～6)个月.密切观察骨痛缓解情况,治疗3个月后行骨扫描了解骨转移灶情况.结果:18例患者中14例骨痛有不同程度缓解,占77.8%,骨扫描示骨转移灶客观反应率为55.5%(10/18).结论:对晚期前列腺癌、在行内分泌治疗后存在骨转移顽固性骨痛患者,153Sm-EDTMP内放射治疗仍有较好效果.
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| 关 键 词： | 前列腺癌 骨转移 骨痛 内分泌治疗 |
| 文章编号： | 0253-3626（2006）03-0417-02 |
| 收稿时间： | 2005-12-21 |
| 修稿时间： | 2005-12-21 |
Evaluation of 153Sm-EDTMP Therapy for Metastasis Prostate Cancer and Pain due to Bony Metastases after Hormone Therapy |
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| TANG Zhaobing.Evaluation of 153Sm-EDTMP Therapy for Metastasis Prostate Cancer and Pain due to Bony Metastases after Hormone Therapy[J].Journal of Chongqing Medical University,2006,31(3):417-418,421. |
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| Authors: | TANG Zhaobing |
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| Abstract: | Objective: To evaluate the effect of Samarium etramthylene phosphoric acid(153Sm-EDTMP) in the treatment of painful bony metastases from prostate cancer after hormone therapy.Methods: 18 patients after being treated with hormone therapy(excision of testes+flutamide) for 3~6 months and with painful bony metastases from prostate cancer were injected 153Sm-EDTMP(dosage:37MBq/kg),After the patients underwent 1~3 dose treatment.The palliation of pain and change of bone metastases on bone scans were evaluated.Results: A significant decrease of bone pain was achieved,making up 77.8%(14/18) and X ray and bone radionuclide imaging exam showed that 2 patients achieved complete focus disappearance,and 8 patients achieved partial focus disappearance.The response rate is 55.5%.Conclusion: 153Sm-EDTMP radiotherapy is efficacious to the refractory painful bone metastases in prostate cancer. |
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| Keywords: | 153Sm-EDTMP |
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