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卡维地洛及美托洛尔对慢性心力衰竭合并糖尿病患者的心功能及胰岛素抵抗的影响
引用本文:陈斌.卡维地洛及美托洛尔对慢性心力衰竭合并糖尿病患者的心功能及胰岛素抵抗的影响[J].安徽医药,2010,14(1):94-96.
作者姓名:陈斌
作者单位:安徽医科大学第一附属医院心内科,安徽,合肥,230022
摘    要:目的 观察卡维地洛和美托洛尔对慢性心力衰竭(chronicheart failure,CHF)合并2型糖尿病(type2 diabetesmellitus,T2DM)患者的心功能及胰岛素抵抗的影响。方法CHF合并T2DM患者130例,根据常规治疗基础上加用卡维地洛与美托洛尔分为卡维地洛组(65例)和美托洛尔组(65例)。治疗12个月。结果(1)卡维地洛组及美托洛尔组心功能均较治疗前改善(P〈0.05)。LVEF均高于治疗前(P〈0.05),舒张末期内径(LVEDd)、舒张末期容积指数(LVEDVI)、收缩末期容积指数(LVESVI)均低于治疗前(P〈0.05)。卡维地洛组疗效优于美托洛尔组(P〈0.05)。(2)卡维地洛组的胰岛素抵抗指数显著低于治疗前(P〈0.05),而美托洛尔治疗前后无明显变化(P〉0.05)。结论卡维地洛和美托洛尔均能明显改善CHF合并T2DM患者的心功能,卡维地洛可改善胰岛素抵抗。

关 键 词:卡维地洛  美托洛尔  心力衰竭  充血性  糖尿病  2型  胰岛素抗药性

Effects of carvedilol and metoprolol on cardiac function and insulin resistance in type 2 diabetes mellitus patients with chronic heart failure
CHEN Bin.Effects of carvedilol and metoprolol on cardiac function and insulin resistance in type 2 diabetes mellitus patients with chronic heart failure[J].Anhui Medical and Pharmaceutical Journal,2010,14(1):94-96.
Authors:CHEN Bin
Institution:Department of Cardiology;The First Affiliated Hospital of Anhui Medical Uuiversity;Hefei;Anhui 230022
Abstract:Aim To evaluate the effects of carvedilol and metoprolol on cardiac function and insulin resistance(IR) in type 2 diabetes mellitus(T2DM) patients with chronic heart failure(CHF).Methods 130 patients with CHF and T2DM were divided into carvedilol group(n=65) and metoprolol group(n=65),with the same basic therapy.The therapy was given for 12 months.Result The cardiac function was improved in two groups.The left ventricular end diastolic dimension(LVEDd),left ventricular end-systolic volume index(LVESVI) and ...
Keywords:carvedilol  metoprolol  heart failure  congesitve  biabetes mellitus  type 2  insulin resistance  
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