Predictors of long-term survival after pancreaticoduodenectomy for peri-ampullary adenocarcinoma: A retrospective study of 5-year survivors

Background

Pancreaticoduodenectomy (PD) is the standard curative treatment for periampullary tumors. The aim of this study is to report the incidence and predictors of long-term survival (≥?5 years) after PD.

Methods

This study included patients who underwent PD for pathologically proven periampullary adenocarcinomas. Patients were divided into 2 groups: group (I) patients who survived less than 5 years and group (II) patients who survived?≥?5 years.

Results

There were 47 (20.6%) long-term survivors (≥?5 years) among 228 patients underwent PD for periampullary adenocarcinoma. Patients with ampullary adenocarcinoma represented 31 (66.0%) of the long-term survivors. Primary analysis showed that favourable factors for long-term survival include age?P?=?0.001], smaller tumor size [OR (95% CI?)=?1.335 (1.032–1.726), P?=?0.028] and Ro resection [OR (95% CI)?=?3.098 (2.095–4.582), P?

Conclusions

The majority of long-term survivors after PD for periampullary adenocarcinoma are patients with ampullary tumor. CA 19-9?