The modulation of venlafaxine on cortical activation of language area in healthy subjects with fMRI study |
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| Authors: | Qi Xie Yan Liu Chun-Yong Li Xue-Zhu Song Jun Wang Li-Xin Han Hong-Min Bai |
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| Institution: | Neurology Department and Rehabilitation Medicine Department, General Hospital of Guangzhou Military Command of PLA, Guangzhou, China. |
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| Abstract: | Rationale Previous studies have shown that selective serotonin reuptake inhibitors, activators of the cortex, apparently improved language functional recovery after brain damage rather than simply affective disorders. Objective Our aim was to determine whether venlafaxine (an agonist of both norepinephrine and 5-hydroxytryptamine) could modulate language cortex function. Methods A double-blind, crossover, randomized design was used to compare two 7-day treatment sessions with either venlafaxine (75?mg per day) or placebo. A functional magnetic resonance imaging experiment and two language function tests were performed on eight healthy males (mean age, 28.25?±?3.15?years) at the end of each session, i.e., study entry, after venlafaxine, and after placebo (days 0, 7, and 18). Hyperactivation (venlafaxine minus placebo >0) or hypoactivation (placebo minus venlafaxine >0) by venlaxafine was assessed on the basis of the activation–baseline contrast. Results The naming score (P?P?
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