The power and pitfalls of IL-12 |
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Authors: | Kerkar Sid P Restifo Nicholas P |
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Institution: | National Heart, Lung, & Blood Institute, and National Cancer Institute. |
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Abstract: | In this issue of Blood, Pegram and colleagues describe the ability to improve adoptive T-cell therapies by engineering T cells to secrete the potent proinflammatory cytokine IL-12.1 These exciting findings significantly extend previous observations made in a murine melanoma model targeting naturally occurring tumor antigens.2,3 |
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