Adaptor protein-3 in dendritic cells facilitates phagosomal toll-like receptor signaling and antigen presentation to CD4(+) T cells期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Adaptor protein-3 in dendritic cells facilitates phagosomal toll-like receptor signaling and antigen presentation to CD4(+) T cells

Authors:	Mantegazza Adriana R Guttentag Susan H El-Benna Jamel Sasai Miwa Iwasaki Akiko Shen Hao Laufer Terri M Marks Michael S

Affiliation:	Department of Pathology & Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Abstract:	Download : Download high-res image (218KB) Download : Download full-size image Highlights? AP-3 is selectively required for optimal MHC-II presentation of phagocytosed antigen ? AP-3-deficient dendritic cells induce impaired CD4⁺ T cell inflammatory responses ? AP-3 regulates TLR4 delivery to phagosomes and subsequent inflammatory signaling ? AP-3 regulates phagosomal peptide:MHC-II complex delivery to the cell surface

Keywords:
本文献已被 ScienceDirect PubMed 等数据库收录！