| 拉米夫定联合肝泰乐治疗慢性乙型肝炎肝纤维化疗效观察 |
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| 引用本文： | 李会同,张新军,孙振华,蒋全德.拉米夫定联合肝泰乐治疗慢性乙型肝炎肝纤维化疗效观察[J].医药世界,2010,12(2):112-113. |
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| 作者姓名： | 李会同 张新军 孙振华 蒋全德 |
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| 作者单位： | 武警南疆指挥部医院内科,新疆喀什844000 |
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| 摘 要： | 目的：观察拉米夫定联合肝泰乐治疗慢性乙型肝炎肝纤维化的疗效。方法：124例慢性乙肝患者随机分为实验组（A组,n=64）和对照组（B组,n=60）,两组治疗前的基线资料无统计学差异（P〉0.05）。对照组给予拉米夫定100mg,1次/d;实验组除按上述方法服用拉米夫定外,给予肝泰乐0.2g,3次/d,疗程1a。观察治疗前后乙肝病毒学标记物、肝功能、HBV-DNA、肝纤维化指标的改变。结果：治疗后A组和B组均有良好的病毒学应答,两组比较无统计学差异（P〉0.05）;实验组和对照组的肝功能指标均有明显改善,但实验组肝功能的指标的改善优于对照组,有统计学差异（P〈0.05）。结论：拉米夫定联合肝泰乐对慢性乙型肝炎肝纤维化的改善具有优于单一用药的疗效,值得进一步推广。
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| 关 键 词： | 肝硬化/药物疗法 肝炎 乙型 慢性/药物疗法 拉米夫定/治疗应用 逆转录酶抑制剂/治疗应用 |
Effects of Combination Lamivudine with Glucurolactone in Treatment of Hepatic Fibrosis Due to Chronic Hepatitis Type B |
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| LI Hui-tong,ZHANG Xin-jun,SUN Zhen-hua,et al..Effects of Combination Lamivudine with Glucurolactone in Treatment of Hepatic Fibrosis Due to Chronic Hepatitis Type B[J].Medicine World,2010,12(2):112-113. |
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| Authors: | LI Hui-tong ZHANG Xin-jun SUN Zhen-hua |
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| Institution: | LI Hui-tong,ZHANG Xin-jun,SUN Zhen-hua,et al.(Department of medical,South Region Comm, Post Hospital of Xinjiang Uygur Autonomous Region Armed Police Force,KaShi 844000,China) |
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| Abstract: | Objective:To investigate the effect of combination lamivudine with glucurolactone in treatment of hepatic fibrosis due to chronic hepatitis type B.Methods:124 cases with chronic hepatitis type B cobined with hepatic fibrosis were divided into experimental group(group A,n=64)and control group(group B,n=60).There was no difference between two groups at baseline data(P>0.05).Patients in group B received lamivudine 100mg once daily for one year.patients in group A received glucurolactone besides lamivudine 100 ... |
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