临床药物评价的有效性

本文是作者在本刊上一期发表题为临床药物评价的意义与方法一文的补充，从以下几个方面阐述了提高上市药物评价有效性问题：四分结果模式；药疗中同一疾病不同严重程度的区别对待；平稳的血药浓度与治疗效应的必要；查明发病机理是治疗学的基石在观地评价综合再分析的结果；在医疗工作中推广非药物疗法。在说明上述问题中，重点引用了1995年美国钙桔抗剂降压治疗评价的教训以及小剂量阿斯匹林用于动脉硬化患者抗血小板疗法的潜在风险。作者强调辩证思维是上市药物评价的指导原则。

The Validity of Clinical Drug Evaluation

As a complementary of the author's paper published in the last issue of the Journal titled Clinical Drug Evaluation:Meaning & Methods,further details concerning increasing validity of postmarketing drug evaluation (PMDE) were given in thispaper. i. e. Quadripartite-resu lted modality;make a distinction between different severity of the same illness in pharmac otherapy; theneed for stable drug level and gently effect;find out the pathogenesis is a cornerstone for therapeutics;to evaluate meta-analysisresults objectively;and promoting non-medicinal drug therapy in medical practice.An explanatory discussion forcused on lessonslearn from evaluation on calcium antagonistS for hypertension cases in U.S. in 1995 and the potential hezard of low dose aspirin foranti-platelet therapy in arteriosclerosis patients.The anthor emphasized that look at things dialectically are guidelines for PMDE.