尿酶早期监测丁胺卡那霉素肾毒性的研究

对１０例使用丁胺卡那霉素（ＡＭＫ）的患者，在进行血药浓度监测的同时，动态观察了ｒ－谷氨酰转肽酶（ｒ－ＧＴ），碱性磷酸酶（ＡＬＰ），乳酸脱氢酶（ＬＤＨ）三种尿酶的变化，同时与血肌酐（ＳＣｒ）变化进行对比，结果实验组用药前后及与对照组相比ＳＣｒ无显著性差异（ｐ＞０．０５），而三种原酶在用药３ｄ后开始明显升高（ｐ值分别小于０．０１，０．０１，０．０５）。研究结果证明：尿酶变化可以早期反映紧实质性损害，动态观察尿酶变化可以判定肾损害程度及演变过程。

Study on Renal Damage of Amikacin by Early Detection of Enzymuria

The changes of three enzytnuria-r-Glutamyl transpeptidase (r-GT), Alkaline phos-phatase (ALP) and Lactate dehydrogenase (LDH)-were detected dynamically in 10 patientswith intravenous drip of Amikacin (AK) 0.4 g/d and were compared with those of Serum crea-inie (SCr), and the drug concentration of AK in blood was also measured at the same time.The activity of these enzymuria increased 3 days later (P<0.01, P<0.01, P<0.05 respectively)while the SCr did not change (P>0.05). The results suggested that the changes of enzymuriamay reflect the renal damage early and judge the level of renal disfunction and development.