脑梗死患者颈动脉粥样硬化与血清超敏C-反应蛋白的相关性研究

目的探讨急性脑梗死患者颈动脉粥样硬化与血清超敏C-反应蛋白（hs—CRP）的相关性。方法对来院就诊的102例急性脑梗死患者和健康体检者96例均进行颈动脉超声检查，测量颈动脉内膜中层厚度（IMT），观察有无颈动脉斑块形成及斑块的性质，同时进行血清hs—CRP浓度的测定。结果两组研究对象IMT正常者中hs—CRP浓度间差异有显著性意义（P〈0．05）。脑梗死组中IMT正常者10例，增厚者19例，生成斑块者73例，3组患者hs—CRP间差异有非常显著性意义（P〈0．01），且两两比较各组患者hs—CRP水平间差异亦均有非常显著性意义（P〈0．01）。颈动脉斑决生成者中稳定斑块者与不稳定斑块者hs—CRP间差异亦有非常显著性意义（P〈0．01）。结论血清hs—CRP与急性脑梗死患者颈动脉粥样硬化的发生有一定相关性，炎症反应可能参与了急性脑梗死颈动脉粥样硬化的形成。

Serum High-Sensitive C-Reactive Protein Level is Associated with Carotid Atherosclerosis in Acute Cerebral Infarct Patients

Objective To study the relationship between serum high-sensitivity C-reactive protein(hs-CRP)level and carotid atherosclerosis in patients with acute cerebral infarct.Methods The serum concentrations of high sensitive C reactive protein(hs-CRP)were measured in one hundred and eighty-eight patients with acute cerebral infarct and in ninty-six healthy people.A Color Doppler Ultrasound system was used to investigate the intimal-medial thickness(IMT)of common carotid artery(CCA)and the plaque of carotid artery.Results Contradisting serum high-sensitivity C-reactive protein level with non carotid atherosclerosis in patients with acute cerebral infarct and in the control group,the former is higher than the latter (P<0.05).The serum concentrations of hs-CRP in the group with IMT increasing were signicantly higher than that in the carotid artery normal group(P<0.01).The serum concentrations of hs-CRP in the carotid artery plaque group were signicantly higher than that in the non-carotid artery plaque group(P<0.01).These findings were also present in the group with IMT increasing(P<0.05).The serum concentrations of hs-CRP in the carotid artery non-stabale plaque group were signicantly higher than that in the -carotid artery stabale plaque group(P<0.01).Conclusion Serum high-sensitivity C-reactive protein level is associated with carotid atherosclerosis in patients with acute cerebral infarct.Inflammatory response might play an important role in the pathogenesis of carotid atherosclerosis with acute cerebral infarct.There is a positive relationship between Inflammation and unstable plaques of carotid atherosclerosis in patients with acute cerebral infarct.