脑梗死急性期血清IL-6、IL-8动态变化及其与脑梗死病情、预后的相关研究

目的探讨脑梗死急性期血清白细胞介素-6(IL-6)、白细胞介素-8(IL-8)的改变与脑梗死的病情、预后的关系,以指导临床诊治。方法收集急性脑梗死患者63例,分别测定发病24h内、第3天和第7天的血清IL-6及IL-8水平,然后分析其与神经功能缺损程度、梗死体积、早期病情恶化及预后的关系。结果脑梗死后血清IL-6及IL-8含量升高,其高峰分别为发病24h内和第3天,达峰时间与入院时中国中风量表(CSS)评分、梗死体积、早期病情恶化无关,而峰值水平与入院时CSS评分、梗死体积、早期病情恶化呈正相关,Logistic回归分析显示24h内的血清IL-6水平是预后的独立预测因素。结论脑梗死后血清IL-6及IL-8水平升高呈时间依赖性,峰值与脑梗死的损伤程度、早期病情恶化有关,IL-6对预后有预示作用。

Dynamic changes of interleukin -6 and interleukin-8 serum levels and their correlation with severity and prognosis in patient of cerebral infarction at acute stage

Objective To investigate the dynamic changes of interleukin-6 (IL-6) and interleukin-8(IL-8) serum levels at acute stage and their correlation with state and prognosis of cerebral infarction. Methods Sixty-three patients with acute cerebral infarction enrolled within 24 hours after onset. The serum specimens were gathered for IL-6 and IL-8 on admission, at the 3rd day and the 7th day of onset. Results The IL-6 and IL-8 serum levels in case group at different times were all significantly higher than those in control group and peaked within 24 hours and at the 3rd day respectively. The peak levels of IL-6 and IL-8 were related with the CSS scale on admission, the infarct size, and early neurological worsening, but so were not the peak times. Stepwise Logistic regression analysis suggested the IL-6 serum levels within 24 hours as independent indicator of prognosis. Conclusions Serum levels of IL-6 and IL-8 increase time-dependently after cerebral infarction .Their peak levels are related with severity and early neurological worsening of cerebral infarction. The IL-6 serum level may predict the prognosis of cerebral infarction.