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| 抗人肝癌188Re-免疫磁性纳米微粒的生物学分布和肿瘤细胞抑制实验 | |
| 引用本文： | 冯彦林,谭家驹,梁生,孙静,温广华,吴校连,夏姣云.抗人肝癌188Re-免疫磁性纳米微粒的生物学分布和肿瘤细胞抑制实验[J].国际放射医学核医学杂志,2007,31(6):321-324,328. |
| 作者姓名： | 冯彦林 谭家驹 梁生 孙静 温广华 吴校连 夏姣云 |
| 作者单位： | 1. 430022,武汉,华中科技大学同济医学院协和医院核医学科;528000,佛山,中山大学附属佛山医院(暨佛山市第一人民医院)核医学科 2. 中山大学附属佛山医院(暨佛山市第一人民医院)核医学科,佛山,528000 3. 上海应用物理研究所,上海,201800 |
| 摘 要： | 目的探讨抗人肝癌188Re-免疫(Hepama-1)磁性纳米微粒免疫学活性、体内生物学分布、肝靶向性及抑瘤作用。方法对比188ReO4-、188Re-Hepama-1、188Re-磁性纳米微粒,研究尾静脉注射188Re-免疫磁性纳米微粒后4h、24h在昆明小鼠体内的分布情况;在肝区外加磁场及无磁场状态下,研究新西兰大白兔体内的肝磁靶向性;采用溴化四甲基唑法,研究4种188Re标记物对肝癌细胞株SMMC-7721的抑制效果。结果188Re-免疫磁性纳米微粒在肝内摄取量最大;在磁区肝组织放射活性较非磁区肝组织明显增加,二者的放射活性比值为1.87;对肝癌细胞株SMMC-7721半数抑制放射性活度仅为188ReO4-的1/4左右。结论188Re-磁性纳米微粒具有良好的磁感应性能、免疫活性及明显的肝靶向性。 |
| 关 键 词： | 铼 肝肿瘤 实验性 磁性纳米微粒 |
| 文章编号： | 1673-4114（2007）06-0321-04 |
| 收稿时间： | 2007-03-13 |
| 修稿时间： | 2007-03-13 |
Experimental study of the biological properties of 188Re-Hepama-1 biologic superparamagnetic nanoparticles |
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| FENG Yan-lin,TAN Jia-jü,LIANG Sheng,SUN Jing,WEN Guang-hua,WU Xiao-lian,XIA Jiao-yun.Experimental study of the biological properties of 188Re-Hepama-1 biologic superparamagnetic nanoparticles[J].International Journal of Radiation Medicine and Nuclear Medicine,2007,31(6):321-324,328. | |
| Authors: | FENG Yan-lin TAN Jia-jü LIANG Sheng SUN Jing WEN Guang-hua WU Xiao-lian XIA Jiao-yun |
| Abstract: | Objective To investigate a new biologic-superparamagnetic nanoparticles, s charact-eristics of immunological activity, biological distributing in vivo, targeting and inhibiting tumoreffect. Methods The experimental group 188Re-Hepama-1-superparamagnetic nanoparticles, and control groups, including 188ReO4-, 188Re-Hepama-1, and 188Re-superparamagnetic nanoparticles, were set up. The distributions were measured after injection 4 h and 24 h by caudal vein of Kuming mice. The magnetic targeting experiments in v... |
| Keywords: | Rhenium Liver neoplasms experimental Superparamagnetic nanoparticles |
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