SPECT/CT 99mTc-Octreotide同机断层融合显像诊断肺癌的价值

目的探讨^99mTc—Octreotide生长抑素受体显像诊断肺癌的价值。方法43例肺部肿瘤病人，静脉注射^99mTc-Octreotide 15min、1h、3h后行前后位平面显像，2～3h行SPECT／CT同机断层融合显像。勾画感兴趣区，分别测定肿瘤和对侧正常肺组织的放射性比值（T／N），并将影像最终诊断结果与病理检查结果进行对比分析。结果^99mTc-Octreotide显像诊断肺癌的灵敏度、特异度和准确度分别为94．4％、85．7％和93．0％。小细胞肺癌（SCLC）的T／N值高于非小细胞肺癌（NSCLC），差异有显著性（t=6．469，P〈0．01）。结论。^99mTc-Octreotide SPECT／CT同机断层融合显像对肺癌具有较高的诊断价值。

CLINICAL SIGNIFICANCE OF 99mTc-Octreotide LABELLED OCTREOTIDE SOMATOSTATIN RECEPTOR SPECT/ CT FUSION IMAGING IN THE DIAGNOSIS OF LUNG CANCER

Objective To evaluate the value of 99mTc-octreotide somatostatin receptor scintigraphy in the diagnosis of lung neoplasm. Methods Patients with pulmonary neoplasm(n=43) were studied with 99mTc-Octreotide scintigraphy.Planar imaging was obtained after injection of 99mTc-octreotide at 15 min,1 h,and 3 h,SPECT/ CT fusion images were taken at 2-3 h after injection.All scintigraphically detected lesions were confirmed histopathologically.Ratios of tumor to normal tissue(T/N) were calculated. Results Sensitivity,specificity and accuracy of 99mTc-octreotide in detection of lung cancer were 94.4%,85.7% and 93.0%,respectively.The T/N ratio in small cell lung cancer was significantly higher than that in non-small cell one(t=6.469,P<0.01). Conclusion 99mTc-octreotide SPECT/ CT fusion imaging is a good method to detect the primary lung cancer.