青岛市6～18岁女性双生子血清硫酸脱氢表雄酮水平的研究

目的探讨青春期女性血清硫酸脱氢表雄酮(DHEAS)的变化趋势,估计遗传与环境因素的相对效应。方法以学校登记为基础募集青岛市6~18岁女性双生子180对,其中同卵双生子(MZ)132对,异卵双生子(DZ)48对,按Tanner标准进行青春发育分期,放免法测定空腹血清DHEAS浓度。结果青春期女生血清DHEAS浓度随年龄增长和青春期进程而增高,Tanner IV期达高峰,Tanner V期略有下降;遗传效应分析显示血清DHEAS浓度偶内平均差、偶内方差为MZDZ;遗传度为0.65,分期估计遗传度分别为乳房未发育组0.92,乳房发育未来潮组0.73,已潮组0.67。结论青春期女性血清DHEAS受遗传因素的控制较强,尤其乳房发育前肾上腺功能初现期。提示在与肾上腺功能初现有关的内分泌失调性疾病的发病中遗传因素可能起重要的作用。

Change of dehydroepiandrosterone in serum of 6-18 year-old twin girls in Qingdao City

Objective To explore the change of serum dehydroepiandrosterone(DHEAS) concentrations throughout the puberty of girls and estimate the effects of genetic and environmental factors on serum DHEAS.Methods The study population consists of 360 girls aged 6 to 18 years:132 pairs monozygotic twins and 48 pairs dizygotic twins, who were all from Qingdao city, Shan-dong province. Anthropometric measurement and pubertal development stage were determined by Tanner standard, fasting serum DHEAS contents were assayed by RIA. Results Serum DHEAS concentrations increased from Tanner I to IV and decreased later, heritability of pubertal girl's serum DHEAS was 0.65. The heritability of 3 different pubertal stages (pre-thelarche, post-thelarche and pre-menarche, and post-menarche) were 0.92, 0.73 and 0.67 respectively.Conclusion Serum DHEAS concentrations of pubertal girls could be mainly influenced by the genetic factors, especially in the period of adrenarche. Therefore, genetic influence might be important in adrenarche-related metabolic disorders.