芸香苷对实验性急性胰腺炎多器官损伤的保护作用

目的探讨芸香苷（Ru）对实验性急性胰腺炎（AP）胰外多器官损伤的影响。方法牛磺胆酸钠（STC）逆行胆胰管注射诱发大鼠AP模型后，立即按Ru15、30、60mg／kg3个剂量持续静脉输注6h，观察AP大鼠多器官功能性指标，包括血清淀粉酶（AMS）、尿素氮（BUN）、肌酐（Cr）、谷丙转氨酶（ALT）、谷草转氨酶（AST）和乳酸脱氢酶（LDH）、动脉血气分析的变化。结果Ru15、30、60mg／kg3个给药剂量组可不同程度降低AP大鼠升高的AMS、BUN、Cr、ALT、AST、LDH。60mg／kg剂量组可升高AP大鼠降低的动脉PO2。结论静脉输注Ru对实验性AP胰外多器官功能损伤具有一定的保护作用。

Protective effect of Rutoside on multi-organ injury during experimental acute pancreatitis

Objective To investigate the effects of Rutoside (Ru) on multi-organ injury during experimental acute pancreatitis (AP). Methods The model of AP was induced by retrograde injection of Sodium Taurocholate(STC) into bilipancreatic duct of rat. Ru (15,30,60mg/kg)was administered with intravenous infusion for 6 h immediately after the induction of AP. Some indicators which reflected the function of multi-organ of AP rats were observed, they were amylase(AMS), blood urea nitrogen(BUN), creatinine(Cr), alanine aminotransferase(ALT), aspartate aminotransferase(AST),lactic dehydrogenase(LDH) and indexes of blood gas analysis. Results Ru(15, 30, 60mg/kg)decreased AMS, BUN, Cr, ALT, AST and LDH, which had increased in AP rats. Ru (60 mg/kg) increased arterial PO_2 in AP rats. Conclusion The study indicates that Ru administered by intravenous infusion exerts certain protective effects on multi-organ function injury in experimental AP rats.