乳腺癌相关信号转导通路的研究进展

乳腺癌的术后辅助全身化疗总是取得不断的进展。从环磷酰胺、甲氨喋呤和氟尿嘧啶的三联ＣＭＦ方案减低患者术后复发和死亡风险开始，辅助化疗方案在不断更新，蒽环类药物以及随后的紫杉醇类药物序贯或者联合应用已经成为目前主打的辅助化疗策略。患者的机体状况、肿瘤特定的生物学表型以及药物的疗效和毒性是制定辅助化疗方案必须综合考虑的因素。传统的预后指标评估患者复发风险仍然十分重要，此外新的基因组工具（如ＯｎｃｏｔｙｐｅＤＸ和Ｍａｍｍａｐｒｉｎｔ）便于我们更有选择地为不同的患者制定个体化的术后辅助治疗。

Optimizing adjuvant chemotherapy in women with breast cancer

Adjuvant treatment for breast cancer is an evolving field.Since the advent of the initial cyclophosphamide,methotrexate and 5-fluorouracil(CMF) regimens,which reduced risk for recurrence and death.Anthracyclines and subsequently taxanes were added to the cytotoxic armamentarium for sequential use or in combination with the adjuvant setting.The efficacy and toxicity of each chemotherapy regimen must be viewed within the context of host comorbidities and the specific biologic phenotype of the tumor.Traditiona...