| 孕哺期母鼠镧暴露所致仔鼠脑组织脂质过氧化及形态学改变的实验研究 |
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| 引用本文： | 姜杰,靳翠红,鲁帅,巫生文,齐鸣,蔡原. 孕哺期母鼠镧暴露所致仔鼠脑组织脂质过氧化及形态学改变的实验研究[J]. 工业卫生与职业病, 2009, 0(2): 65-68 |
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| 作者姓名： | 姜杰 靳翠红 鲁帅 巫生文 齐鸣 蔡原 |
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| 作者单位： | 大连市疾病预防控制中心,辽宁,大连,116021;中国医科大学公共卫生学院,辽宁,沈阳,110001 |
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| 基金项目： | 辽宁省科学技术计划项目(2005225008-3) |
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| 摘 要： | 目的探讨孕哺期母鼠镧暴露对子代大鼠脑组织的脂质过氧化作用及海马形态结构的影响。方法通过母鼠孕哺期染镧的方法检测子代断乳大鼠海马和大脑皮层组织丙二醛(MDA)含量、还原型谷胱甘肽(GSH)含量、谷胱甘肽过氧化物酶(GSH-Px)活力、超氧化物歧化酶(SOD)活力和总抗氧化能力(T-AOC);光镜下观察海马组织形态结构改变。结果随着剂量的增加子代大鼠海马和大脑皮质MDA水平明显升高,GSH含量和GSH-Px活力下降,脂质过氧化作用明显增强,T-AOC明显降低,海马组织形态结构发生病理性改变。结论孕哺期母鼠镧暴露对子代大鼠中枢神经系统具有损伤作用,其原因可能与脂质过氧化有关。
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| 关 键 词： | 三氯化镧 海马 MDA GSH SOD GSH-Px T-AOC 形态学 |
Effect of Lanthanum Exposure of Female Rats during Pregnancy and Lactation on Lipid Peroxidation in Brain and Morphological Changes in Hippocampus Cells of Their Offspring |
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| JIANG Jie,JIN Cui-hong,LU Shuai,WU Sheng-wen,QI Ming,CAI Yuan. Effect of Lanthanum Exposure of Female Rats during Pregnancy and Lactation on Lipid Peroxidation in Brain and Morphological Changes in Hippocampus Cells of Their Offspring[J]. Industrial Health and Occupational Diseases, 2009, 0(2): 65-68 |
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| Authors: | JIANG Jie JIN Cui-hong LU Shuai WU Sheng-wen QI Ming CAI Yuan |
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| Affiliation: | * Dalian Center For Disease Control and Prevention;Dalian 116021 China |
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| Abstract: | Objective To explore the effect of lanthanum exposure of female rats during pregnancy and lactation on lipid peroxidation in brain and morphological changes in hippocampus cells of their offspring.Methods The female rats were administrated with lanthanum from pregnancy to the end of lactation.The malondialdehyde(MDA),reduced glutathione(GSH) content,glutathione peroxidase(GSH-Px) vitality,and superoxide dismutase(SOD) vitality and total antioxidant capacity(T-AOC) were tested.The morphological changes were ... |
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| Keywords: | LaCl3 Hippocampus MDA GSH GSH-Px SOD T-AOC Morphology |
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