三乙醇胺染毒对大鼠机体危害的研究

[目的]实验观察三乙醇胺染毒大鼠血清脂质过氧化代谢产物(MDA)含量，超氧化歧化酶(SOD)和全血谷胱甘肽氧化酶(GSH-PX)的活性及组织病理学改变。[方法]32只大鼠分别经染毒不同剂量的三乙醇胺(250、500、750mg/kg)，每周1次，7周后断头取血检测酶学指标，同时进行大体剖检和组织病理学检查。[结果]染毒大鼠血清MDA含量明显增高，SOD和全血GSH-PX活性明显降低，与对照组比较差异均有统计学意义(P＜0.01);500mg/kg、750mg/kg染毒组脏器系数增大，肝、脾、肾器官有不同程度的病理学改变。[结论]接触一定量的三乙醇胺可增强染毒大鼠脂质过氧化水平，对染毒大鼠肝、脾、肾脏组织有损伤作用。

Study on Damages toOrganism of Rats Poisoned with Triethanolamine

[Objective]To measure the contents of MDA in serum, the activities of SOD in serum and GSH-PX in whole blood, and the histopathological changes of some organs in rats poisoned with triethanolamine. [Methods］32 rats were poisoned with different doses of triethanolamine (250,500,750 mg/kg) once a week. After 7 weeks, the index of enzymology in blood obtained by breaking off the rat's heads were measured, and gross and histopathological changes were observed. [Results]There was significant increase in the contents of MDA and decrease in the activities of SOD in serum and GSH-PX in whole blood in experimental rats compared with those in controls (P＜0.01). The ratio of viscera of the experimental rats exposed to 500 mg/kg and 750 mg/kg was increased, there were also pathological changes to some extent in liver, spleen and kidney. [Conclusions]A certain amount of triethanolamine may increase the contents of lipid peroxides and make injuries to the liver, spleen and kidney of rats.