| 安宫牛黄丸药效组分对小鼠总抗氧化能力及耐缺氧存活时间的影响 |
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| 引用本文： | 李佳,张贵君,赵晖,毕赢,侯栩.安宫牛黄丸药效组分对小鼠总抗氧化能力及耐缺氧存活时间的影响[J].辽宁中医药大学学报,2010(2). |
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| 作者姓名： | 李佳 张贵君 赵晖 毕赢 侯栩 |
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| 作者单位： | 北京中医药大学中药学院;首都医科大学; |
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| 摘 要： | 目的:利用内毒素所致的脑损伤模型,以总抗氧化能力及耐缺氧存活时间为指标,观察安宫牛黄丸药效组分与安宫牛黄丸的等效性,探讨中药药效组分理论的可行性。方法:通过腹腔注射内毒素制造脑损伤模型,用安宫牛黄丸药效组分进行防治,测定其耐缺氧的存活时间,通过生化检测的方法,选取脑组织匀浆测定其总抗氧化能力(T-AOC),观察其变化。结果:(1)安宫牛黄丸药效组分组小鼠存活时间为(35.10±9.06)min,安宫牛黄丸组为(41.00±16.20)min;(2)内毒素致脑损伤小鼠总抗氧化能力为0.81±0.63;(3)安宫牛黄丸药效组分(0.099g/kg)内毒素致脑损伤小鼠总抗氧化能力为3.04±2.54。结论:安宫牛黄丸药效组分及安宫牛黄丸均可以明显提高内毒素致脑损伤小鼠的耐缺氧存活时间及总抗氧化能力。
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| 关 键 词： | 内毒素 安宫牛黄丸药效组分 存活时间 总抗氧化能力 |
The Impact of Angongniuhuang Boluses' Effective Components on Total Antioxidant Capacity and Survival Time of Hypoxia on Mice with Endotoxin-Induced Brain Injury |
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| LI Jia,ZHANG Gui-jun,ZHAO Hui,BI Ying,HOU Xu.The Impact of Angongniuhuang Boluses' Effective Components on Total Antioxidant Capacity and Survival Time of Hypoxia on Mice with Endotoxin-Induced Brain Injury[J].Journal of Liaoning University of Traditional Chinese Medicine,2010(2). |
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| Authors: | LI Jia ZHANG Gui-jun ZHAO Hui BI Ying HOU Xu |
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| Institution: | 1. Beijng University of Chinese Medicine/a>;Beijing 100102/a>;China/a>;2.Capital Medical University/a>;Beijing 100069/a>;China |
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| Abstract: | Objective:The use of endotoxin-induced model of brain injury to total antioxidant capacity and hypoxia survival time,observe the efficacy AnGong Niuhuang Boluses'effective components,and explore the efficacy of Chinese medicine theory component feasibility. Methods:The brain injury models is made of endotoxin intraperitoneal injection. Determination of the survival time of the hypoxia.Selected brain tissue and measured total antioxidant capacity (T-AOC). Observed the changes caused of the protective functio... |
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| Keywords: | endotoxin Angong Niuhuang Boluses'effective components hypoxia survival time total antioxidant capacity |
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