凝血和纤溶相关指标对判断AP病情和预后的意义

目的：探讨凝血、纤溶相关指标对判断急性胰腺炎（AP）病情和预后的意义。方法：将99例AP患者依病情分为A、B、C、D四组。回顾性分析四组患者血小板计数（PLT）、凝血酶原时间（PT）、活化部分凝血酶时间（APTT）、纤维蛋白原（FIB）、D二聚体（D-D）水平与临床表现及预后的关系。结果：A组、B组比较,PLT、PT、FIB、D-D四项指标差异明显（P〈0.05或P〈0.01）;B组、C组比较,APTT一项存在差异（P〈0.01）;C组、D组比较,PLT、PT、APTT、FIB、D-D五项指标均存在明显差异（P〈0.05或P〈0.01）。从A组到D组,各项检测指标逐渐恶化。结论：PLT、PT、APTT、FIB、D-D的含量变化,与AP严重程度及预后密切相关;临床可以通过检测PLT、PT、APTT、FIB、D-D的含量,作为判断AP严重程度和估计预后的重要指标。

Prognostic Significance of Changes of Several Coagulation and Fibrinolysis Parameters in Patients with Acute Pancreatitis (AP)

Objective To study the prognostic significance of changes of several coagulation and fibrinolysis parameters in patients with AP.Methods Platelet count(PLT),prothrombin time(PT),activated partial thrombin time(APTT),blood fibrinogen(FIB) and D-dimer(D-D) levels were measured with biochemistry in 99 patients with AP.These 99 patients were of 4 groups: Group A: simple AP,n=35,Group B: with SIRS,n=37,Group C: with SIRS and MOD,n=19,Group D: mortality within 15 days,n=8.Results Worsening of 4/5 parameters(PLT,P...