| 食管鳞癌DNA甲基化的研究进展 |
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| 引用本文： | 王长春,凌志强. 食管鳞癌DNA甲基化的研究进展[J]. 国际肿瘤学杂志, 2010, 37(9). DOI: 10.3760/cma.j.issn.1673-422X.2010.09.016 |
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| 作者姓名： | 王长春 凌志强 |
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| 作者单位： | 1. 浙江省立同德医院胸外科
2. 浙江省肿瘤研究所 |
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| 基金项目： | 浙江省自然科学基金资助项目，人事部留学人员科技活动项目择优资助项目，浙江省科技计划 |
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| 摘 要： | 近年来研究结果表明,相关抑癌基因启动子区超甲基化导致的基因表达紊乱已成为食管癌发病机制研究的热点之一.众多研究表明DNA甲基化在食管癌的发生、侵袭和转移过程中发挥了积极的作用,外周血DNA甲基化谱可作为食管癌早期诊断、预后判断及随访的检测指标,有望将抑癌基因去甲基化作为食管癌的治疗靶点.
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| 关 键 词： | 食管肿瘤 DNA甲基化 |
Research progress on DNA methylation of esophageal squamous cell carcinoma |
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| WANG Chang-chun,LING Zhi-qiang. Research progress on DNA methylation of esophageal squamous cell carcinoma[J]. Journal of International Oncology, 2010, 37(9). DOI: 10.3760/cma.j.issn.1673-422X.2010.09.016 |
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| Authors: | WANG Chang-chun LING Zhi-qiang |
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| Abstract: | In recent year, one of the hot topics in esophageal carcinoma research is the impaired gene expression resulted from hypermethylation within the promoter regions of rumor suppressor genes. Many studies suggested that DNA methylation plays an important role in the initiation, invasion, and metastasis of esophageal carcinoma. DNA methylation spectrum in peripheral blood may be used as markers for early diagnose, prognosis prediction and follow up in esophageal cancer patients. De-methylation of tumor suppressor genes may become a target of esophageal carcinoma therapy. |
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| Keywords: | Esophageal neoplasms DNA methylation |
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