| 普伐他汀对高血压患者脉压和动脉弹性的影响 |
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| 引用本文： | 杨波,张明.普伐他汀对高血压患者脉压和动脉弹性的影响[J].数理医药学杂志,2008,21(6). |
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| 作者姓名： | 杨波 张明 |
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| 作者单位： | 湖北省中山医院,武汉,430033 |
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| 摘 要： | 目的:评价普伐他汀对高血压患者脉压和动脉弹性的影响。方法:选择54例正在规律服用降压药物治疗并且脉压≥60mmHg的高血压患者,随机分成治疗组和对照组,每组各27例,治疗组在原降压药物的基础上加服普伐他汀(20mg/d),对照组则继续服用原降压药物不变,在治疗前及治疗16周以后分别检测患者的血压、大动脉和小动脉弹性指数(C1和C2)。结果:普伐他汀组治疗后的收缩压(SBP)、脉压(PP)和C2较对照组有明显改善(P<0.05),C1则无显著改变(P>0.05)。结论:普伐他汀能明显改善高血压患者的小动脉弹性,从而起到降低脉压的作用。
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| 关 键 词： | 普伐他汀 高血压 脉压 动脉弹性 |
Effect of Pravastatin on Pulse Pressure and Arterial Elasticity of Patients with Essential Hypertension |
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| Yang Bo,et al.Effect of Pravastatin on Pulse Pressure and Arterial Elasticity of Patients with Essential Hypertension[J].Journal of Mathematical Medicine,2008,21(6). |
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| Authors: | Yang Bo |
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| Abstract: | Objective:To evaluate the effect of pravastatin on pulse pressure and arterial elasticity of patients with essential hypertension. Methods:54 patients with pulse pressure being 60mmHg or above , were randomly divided into two groups: treatment group(n=27) was given pravastatin (20mg/d )and unchanged in the control group(n=27)on the basis of the original treatment for 16 weeks. Brachial blood pressure , large and small arterial elastic indexes (C1and C2)were measured before and after treatment. Results:In pravastatin group , systolic blood pressure and pulse pressure were decreased significantly(P<0.05),C2 was increased (P<0.05), while no change for C1 was shown(P>0.05). Conclusion:Pravastatin might reduce pulse pressure through improvement of small arterial elasticity in hypertensives. |
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| Keywords: | pravastatin hypertension pulse pressure arterial elasticity |
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