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Production,characterization and application of monoclonal antibodies against the organophosphorus nerve agent Vx |
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| Authors: | Yun-xiang Ci Yong-xin Zhou Zhen-quan Guo Kang -Tai Rong Wen-bao Chang |
| Affiliation: | (1) Department of Chemistry, Peking University, Beijing, 100871, China, CN;(2) College of Life Science, Peking University, Beijing, 100871, China, CN;(3) Institute of Pharmacology and Toxicology, Beijing, 100850, China, CN |
| Abstract: | Two monoclonal antibodies (Vx-BB8 and Vx-EA11) to the chemical warfare agent Vx were produced and characterized. A competitive inhibition enzyme immunoassay was developed to detect Vx concentrations as low as 3.7×10-7–3.7×10-6 mol/l in biological samples. Vx-BB8 400 μg given intravenously immediately before 1×LD95 Vx or 400 μg Vx-BB8 intraperitoneally 1.5 h–3 days before 1×LD95 Vx could protect all the tested mice from death. Received: 14 October 1994/Accepted: 2 February 1995 |
| Keywords: | Monoclonal antibodies Competitive inhibition enzyme immunoassay Vx Detection |
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