| 正交试验优选芩柏软膏提取工艺 |
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| 引用本文： | 曾祖平,赵小伟,辛颖,何薇,王永红,赵伟峰. 正交试验优选芩柏软膏提取工艺[J]. 中国医院药学杂志, 2005, 25(10): 912-914 |
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| 作者姓名： | 曾祖平 赵小伟 辛颖 何薇 王永红 赵伟峰 |
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| 作者单位： | 1. 北京市中医研究所,北京,100010
2. 首都医科大学中医药学院2000级,北京,100013 |
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| 基金项目： | 北京市中医药科技发展基金 |
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| 摘 要： | 目的:优选芩柏软膏中黄芩、黄柏的提取工艺.方法:设计L9(34)正交试验,采用HPLC法和薄层层析法测定黄芩苷及盐酸小檗碱含量作为评价指标,优化黄芩和黄柏的提取工艺.结果:黄芩提取时主要影响因素为乙醇浓度,差异有极显著性(P＜0.01),乙醇用量、提取次数及时间为次要影响因素,具有显著性差异(P＜0.05);黄柏提取时主要影响因素为提取次数及时间,具有显著性差异(P＜0.05).结论:优选的黄芩、黄柏提取工艺重现性良好,稳定可行.
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| 关 键 词： | 黄芩 黄芩苷 黄柏 盐酸小檗碱 正交设计 |
| 文章编号： | 1001-5213(2005)10-0912-03 |
| 收稿时间： | 2004-11-08 |
| 修稿时间： | 2004-11-08 |
Optimization the extraction process of Qinbai ointment |
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| ZENG Zu-ping,ZHAO Xiao-wei,XIN Ying,HE Wei,WANG Yong-hong,Zhao Wei-feng. Optimization the extraction process of Qinbai ointment[J]. Chinese Journal of Hospital Pharmacy, 2005, 25(10): 912-914 |
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| Authors: | ZENG Zu-ping ZHAO Xiao-wei XIN Ying HE Wei WANG Yong-hong Zhao Wei-feng |
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| Affiliation: | Beijing Institute of TCM, Beijing 100010, China |
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| Abstract: | OBJECTIVE To optimize the extraction process of Radix Scutellaria and Cortex Phellodendri in Qinbai ointment.METHODS The optimum extraction was investigated by the orthogonaL design,Baicalin was determined by HPLC and berberine hydrochloride by TLCS.RESULTS It has extremely remarkable difference(P<(0.01)) in the concentration of ethanol in the extraction process of Radix Scutellaria,draw number of times and time have remarkable difference(P<(0.05)) in the extraction process of Cortex Phellodendri.CONCLUSION This Method is stable and reliable. |
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| Keywords: | Radix Scutellaria baicalin Cortex Phellodendri berberine hydrochloride orthogonal design |
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