英夫利昔单抗治疗类风湿关节炎患者的护理

报道英夫利昔单抗治疗类风湿关节炎患者的护理体会。在使用该药时严格低温保存，即用即取；药物现配现用，选择小号注射器的针头溶解药液，避免药液浪费；密切观察用药不良反应，如输液反应、呼吸道感染、结核感染、白细胞减少、肝功能异常等；因为该药的给药时间是按周排列的，不是传统的集中一个时间段每天用药的规律，不需要住院，因此加强对患者用药依从性的教育，以免延时用药，影响疗效。熟悉药物特性，如药物的作用特点、疗效标准、安全性、剂量、疗程、联合用药、每次用药前的检查等，了解患者治疗进展，及时与患者沟通，了解患者的感受，密切观察患者用药疗效，为医生及时调整治疗方案提供依据。21例类风湿关节炎患者在第0、2、6周及以后每隔8周静脉输注英夫利昔单抗3mg／kg，采用美国风湿病学会疗效评定标准，在用药后第1天、第2周、第6周、第14周ACR20改善分别为7例（33％）、9例（43％）、15例（72％）、18例（86％）。

The Nursing of Rheumatoid Arthritis Patients Treated with Infliximab

The authors report their experience in nursing rheumatoid arthritis patients treated with Infliximab. They suggest the drug should be stored rigidly at lower temperature and be dissolved with small size of needle right at preparation; the adverse reactions should be closely observed like transfugion reactions, infection of respiratory tract, tuberculosis infection, reduction of leucocytes, and abnormities in hepatic＇ function. The patients should be educated in compliance in case they delay use of the drug and the therapeutic effect is detained. The nurses should know well about the features of the drug like the drug action, standard for therapeutic effect, safety, dosage, treating course, drugs for combination, pre-administration examinations. They also keep pace of progress in treatment and communicate with patients, know their feelings and observe the therapeutic effect so that the doctors can modulate the therapy. 21 rheumatoid arthritis patients in the study received venous transfusion of Infliximab at weeks 0, 2 and 6, and then at a dosage of 3 mg/kg once every eight weeks. In line with the standard of ACR, the improvement rates of ACR20 at day 1, weeks 2, 6 and 14 were 33% （7 cases）, 43% （9 cases）, 72% （15 cases） and 86% （18 cases）, respectively.