| 治疗阿尔茨海默病新药盐酸美金刚 |
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| 引用本文： | 罗京京,何玲,刘国卿.治疗阿尔茨海默病新药盐酸美金刚[J].中国新药杂志,2006,15(9):742-744. |
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| 作者姓名： | 罗京京 何玲 刘国卿 |
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| 作者单位： | 中国药科大学药理教研室,南京,210009 |
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| 摘 要： | N-甲基-D-天门冬氨酸(NMDA)受体阻滞剂盐酸美金刚是FDA批准的第1个用于治疗中、重度阿尔茨海默病(Alzheimer's disease,AD)的药物,主要通过调节脑内谷氨酸水平发挥作用。临床研究表明,盐酸美金刚是一种安全、有效,且较有市场前景的药物,单用或与多奈哌齐联用都有明显的治疗作用;口服20 mg·d~(-1)对中、重度AD患者的认知、行为能力等方面都有明显改善。
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| 关 键 词： | 盐酸美金刚 阿尔茨海默病 NMDA受体阻滞剂 学习记忆 |
| 文章编号： | 1003-3734（2006）09-0742-03 |
| 收稿时间： | 2006-01-06 |
| 修稿时间： | 2006年1月6日 |
Memantine: a new drug for Alzheimer's disease |
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| LUO Jing-jing,HE Ling,LIU Guo-qing.Memantine: a new drug for Alzheimer''''s disease[J].Chinese Journal of New Drugs,2006,15(9):742-744. |
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| Authors: | LUO Jing-jing HE Ling LIU Guo-qing |
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| Abstract: | Memantine,the first and only representative of a new class of Alzheimer drug-a mod- erate affinity NMDA-receptor antagonist,was approved for treatment of moderate to severe Alzheimer's disease in Europe and US.Memantine appears to protect the brain's nerve cells against glutamate,a mes- senger chemical released in excess amounts by cells damaged by Alzheimer's disease or certain other neu- rological disorders.Clinically,monotherapy or combination of memantine with donepezil shows significant improvements of cognition and action abilities in patients with moderate or severe AD.AD patients are evident to get huge benefits in the treatment of memantine. |
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| Keywords: | memantine hydrochloride Alzheimer's disease NMDA receptor antagonist learning memory |
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