| 唾液酸黏附素Siglec-1在疾病中作用的研究进展 |
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| 引用本文： | 李克雷,李想,丛喆,薛婧.唾液酸黏附素Siglec-1在疾病中作用的研究进展[J].中国比较医学杂志,2017,27(12):109-114. |
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| 作者姓名： | 李克雷 李想 丛喆 薛婧 |
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| 作者单位： | 北京协和医学院比较医学中心, 中国医学科学院医学实验动物研究所, 卫生部人类疾病比较医学重点实验室, 国家中医药管理局人类疾病动物模型三级实验室, 北京 100021,北京协和医学院比较医学中心, 中国医学科学院医学实验动物研究所, 卫生部人类疾病比较医学重点实验室, 国家中医药管理局人类疾病动物模型三级实验室, 北京 100021,北京协和医学院比较医学中心, 中国医学科学院医学实验动物研究所, 卫生部人类疾病比较医学重点实验室, 国家中医药管理局人类疾病动物模型三级实验室, 北京 100021,北京协和医学院比较医学中心, 中国医学科学院医学实验动物研究所, 卫生部人类疾病比较医学重点实验室, 国家中医药管理局人类疾病动物模型三级实验室, 北京 100021 |
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| 基金项目： | 国家科学项目自然基金，青年科学基金项目（81301437）；科技部重大专项（2014ZX10001OO1-001-004，2014ZX10001OO1-002-006）。 |
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| 摘 要： | 唾液酸黏附素(Siglec-1或CD169)是表达于组织的巨噬细胞上免疫球蛋白超家族类黏附分子。在炎症反应中,Siglec-1可调节MIP-1α/β、MCP-1、MIP-2等细胞因子的分泌,促进炎症反应的发生;在病毒感染过程中,Siglec-1可通过介导病原体与巨噬细胞的的结合,促进病毒感染和吞噬;在对免疫的调节过程中,Siglec-1既可也以抑制IFN-α的过量表达,抑制固有免疫,也可抑制DC细胞活性,降低适应性免疫。本文主要阐述了Siglec-1在病原体感染、炎症反应和免疫调节中最新研究进展。
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| 关 键 词： | Siglec-1 炎症反应 免疫调节 HIV |
| 收稿时间： | 2017/6/1 0:00:00 |
Advances in research on the role of Siglec-1 in diseases |
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| LI Ke-lei,LI Xiang,CONG Zhe and XUE Jing.Advances in research on the role of Siglec-1 in diseases[J].Chinese Journal of Comparative Medicine,2017,27(12):109-114. |
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| Authors: | LI Ke-lei LI Xiang CONG Zhe and XUE Jing |
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| Institution: | Comparative Medicine Center, Peking Union Medical College(PUMC) & Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences(CAMS);Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health;Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing 100021, China,Comparative Medicine Center, Peking Union Medical College(PUMC) & Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences(CAMS);Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health;Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing 100021, China,Comparative Medicine Center, Peking Union Medical College(PUMC) & Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences(CAMS);Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health;Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing 100021, China and Comparative Medicine Center, Peking Union Medical College(PUMC) & Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences(CAMS);Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health;Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing 100021, China |
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| Abstract: | |
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| Keywords: | Siglec-1 Inflammation Immunoregulation HIV |
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