fMRI memory assessment in healthy subjects: a new approach to view lateralization data at an individual level |
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Authors: | Maria Strandberg Christina Elfgren Peter Mannfolk Johan Olsrud Lars Stenberg Danielle van Westen Elna-Marie Larsson Ia Rorsman Kristina K?ll??n |
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Institution: | (1) Department of Neurology, Dept of Clinical Sciences, Lund University Hospital, 221 85 Lund, Sweden;(2) Division of Geriatric Psychiatry, Dept of Clinical Sciences, Lund University Hospital, 221 85 Lund, Sweden;(3) Diagnostic Radiology, Dept of Clinical Sciences, Lund University Hospital, 221 85 Lund, Sweden;(4) Department of Radiology, Uppsala University Hospital, 75185 Uppsala, Sweden |
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Abstract: | We present a comprehensive and clinically applicable fMRI test—including both a verbal and a visuospatial task—for assessment
of hemispheric specific memory in the medial temporal lobe (MTL). fMRI data was collected from 15 healthy right-handed volunteers.
Whole-brain activation was analyzed as well as activation in two regions of interest: the MTL and the anterior speech area.
Laterality indices (LI) and LI-curves were calculated using the LI toolbox of Wilke and Lidzba, 2007. The fMRI paradigms successfully
visualized memory-related activity in the MTL, the verbal memory measure also provided information of language lateralization.
Eleven subjects showed left lateralized verbal encoding in the MTL, visuospatial memory activation was divided equally between
left and right, and 14/15 subjects had left lateralized language. Lateralization data at the group level were consistent with
previous studies, but a variety of activation effects were found at the individual level indicating differences in strategy
during verbal and visuospatial processing. Further studies using the presented method are needed to determine its clinical
usefulness. |
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