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| 电针对拟老年性痴呆大鼠学习记忆功能和海马CA_1区突触表达的影响 | |
| 引用本文： | 王威,唐伟,孙忠人.电针对拟老年性痴呆大鼠学习记忆功能和海马CA_1区突触表达的影响[J].中国中医药科技,2011,18(1):1-2,94. |
| 作者姓名： | 王威 唐伟 孙忠人 |
| 作者单位： | 1. 大连大学附属中山医院·大连,116001 2. 大连大学附属新华医院·大连,116001 3. 黑龙江中医药大学·哈尔滨,150040 |
| 摘 要： | 目的：探讨电针对拟老年性痴呆（AO）大鼠学习记忆功能和海马CA1区突触可塑性的影响。方法：采用腹腔注射D-半乳糖、东莨菪碱,胃饲三氯化铝（A lC l3）制备多因素损伤拟老年性痴呆动物模型,在造模同时给予电针干预,应用跳台实验检测大鼠学习和记忆能力,HE染色,光镜观察海马CA1区形态学变化,免疫组化法测定海马CA1区突触素表达水平。结果：电针能明显改善拟AD大鼠学习记忆能力,增加海马CA1区神经元数目,上调突触素表达。结论：电针可促进海马CA1区重建,提高突触素表达可能是其改善拟AD大鼠学习记忆功能的机制之一。 |
| 关 键 词： | 阿尔茨海默病/针灸疗法 记忆/针灸效应 海马/针灸效应 大鼠 |
Effects of Electrotherapy on Learning and Memory Function of Alzheimer' s Disease Rats and Synaptic Plasticity Expression in Hippocampus CA1 Region |
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| WANG Wei,TANG Wei,SUN Zhongren.Effects of Electrotherapy on Learning and Memory Function of Alzheimer' s Disease Rats and Synaptic Plasticity Expression in Hippocampus CA1 Region[J].Chinese Journal of Traditional Medical Science and Technology,2011,18(1):1-2,94. | |
| Authors: | WANG Wei TANG Wei SUN Zhongren |
| Institution: | WANG Wei,TANG Wei,SUN Zhongren(Zhongshan Hospital Affiliated with Dalian University,Dalian116001) |
| Abstract: | Objective: To explore the effects of electro-acupuncture on learning and memory function of Alzheimer's disease rats and their synaptic plasticity expression in hippocampus CA1 region.Methods: Establishing model with Alzheimer's disease by injecting D-galactose and scopolamine,feeding AlCl3,electro-acupuncture was given to intervene at the same time.Rats' learning and memory function was determined by step-down test,the morphologic changes of rats' hippocampus CA1 region was observed by HE staining,the syna... |
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