| 霉酚酸酯对实验性自身免疫性脑脊髓炎的治疗作用 |
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| 引用本文： | 谭晓姝,王顺和. 霉酚酸酯对实验性自身免疫性脑脊髓炎的治疗作用[J]. 第三军医大学学报, 2009, 31(24): 2452-2454 |
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| 作者姓名： | 谭晓姝 王顺和 |
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| 作者单位： | 重庆医科大学基础医学院病理学教研室,重庆,400016 |
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| 摘 要： | 目的 探讨霉酚酸酯(myeophenolate mofetil,MMF)对实验性自身免疫性脑脊髓炎(experimental autoimmune encephalomyelitis,EAE)的治疗作用.方法 采用豚鼠全脊髓匀浆和完全弗氏佐剂(CFA)为抗原,免疫Wistar大鼠复制急性EAE模型,给了MMF灌胃治疗,观察其埘临床症状及病理学改变的影响.结果 与EAE模型组相比,MMF治疗组的临床症状减轻,且迅速缓解,病程明显缩短.病理学观察显示EAE急性期中枢神经系统大量炎症细胞浸润,在血管周围形成"血管袖套"状结构,并向周围实质扩散,病变区可见明显的髓鞘脱失和轴突损伤;MMF治疗后病变范围及程度明显减轻.结论 MMF对EAE大鼠具有明显的治疗作用,可有效控制EAE的临床病情,减轻中枢神经系统的病理损害.
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| 关 键 词： | 实验性自身免疫性脑脊髓炎 霉酚酸酯 病理学 大鼠 豚鼠 |
Therapeutic effect of mycophenolate mofetil on autoimmune encephalomyelitis in Wistar rats |
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| TAN Xiao-shu,WANG Shun-he. Therapeutic effect of mycophenolate mofetil on autoimmune encephalomyelitis in Wistar rats[J]. Acta Academiae Medicinae Militaris Tertiae, 2009, 31(24): 2452-2454 |
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| Authors: | TAN Xiao-shu WANG Shun-he |
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| Affiliation: | TAN Xiao-shu,WANG Shun-he (Department of Pathology,Faculty of Basic Medical Sciences,Chongqing Medical University,Chongqing 400016,China) |
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| Abstract: | Objective To investigate the therapeutic effect of mycophenolate mofetil (MMF) on rats with experimental autoimmune encephalomyelitis (EAE).Methods The guinea pig spinal cord homogenate (GPSCH) and complete Freund's adjuvant were used as the antigen to induce the acute EAE model in Wistar rats which were verified according to clinical scoring.Totally 36 rats were randomly and equally divided into 3 groups,that is,normal control,EAE group and MMF treatment group.In 10 d after immunization,normal saline or MM... |
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| Keywords: | Wistar experimental autoimmune encephalomyelitis mycophenolate mofetil patholog rats Wistar guineapigs |
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