Metastatic basaloid-squamous cell carcinoma of the esophagus treated by 5-fluorouracil and cisplatin |
| |
Authors: | Shibata Yoshihiro Baba Eishi Ariyama Hiroshi Miki Ryusuke Ogami Nobumichi Arita Shuji Qin Baoli Kusaba Hitoshi Mitsugi Kenji Noshiro Hirokazu Yao Takashi Nakano Shuji |
| |
Institution: | 1. First Department of Internal Medicine and Department of Biosystemic Science of Medicine, Graduate School of Medicine, Kyushu University,Fukuoka, Japan 2. Department of Surgery and Oncology,Graduate School of Medical Sciences, Kyushu University, Japan 3. Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Japan |
| |
Abstract: | Basaloid squamous cell carcinoma (BSC) of the esophagus is a rare malignant disease. We report here a patient with recurrent esophageal BSC, who was successfully treated by systemic chemotherapy containing 5-fluorouracil (5-FU) and cisplatin (CDDP). A 57-year-old woman was diagnosed as having squamous cell carcinoma of the esophagus upon endoscopic examination. Curative esophagectomy with lymph node dissection was performed under the thoracoscope. The pathological diagnosis of the surgical specimen was BSC.Five months after operation, the patient was diagnosed as having a recurrence of the BSC with metastases to the liver and spleen, and a right paraclavicular lymph node. She was given systemic chemotherapy consisting ofcontinuous infusion of 800 mg/d of 5-FU and 3 h infusion of 20 mg/d of CDDP for 5 consecutive days every 4 wk. The metastatic lesions in the spleen and right paraclavicular lymph node disappeared, and the liver metastasis was apparently reduced in size after 2 courses of chemotherapy. The tumor regression was seen over 6 courses, with progression afterwards.Although subsequent treatment with CPT-11 and CDDP was not effective, docetaxel and vinorelbine temporarily controlled the tumor growth for 2 mo. 5-FU and CDDP combination may be useful for the patients with advanced BSC. |
| |
Keywords: | Basaloid-squamous cell carcinoma Esophagus Chemotherapy |
本文献已被 维普 万方数据 PubMed 等数据库收录! |
|