| 缺血再灌注损伤的肾小管细胞ATP酶和自由基代谢的变化 |
| |
| 引用本文： | 黄珀,邓勇,郭勇,冯志强. 缺血再灌注损伤的肾小管细胞ATP酶和自由基代谢的变化[J]. 泸州医学院学报, 2003, 26(5): 393-394 |
| |
| 作者姓名： | 黄珀 邓勇 郭勇 冯志强 |
| |
| 作者单位： | 泸州医学院病理生理学教研室,四川泸州,646000 |
| |
| 基金项目： | 四川省教委课题 (97- 133) 20 0 2 - 10 - 2 9 |
| |
| 摘 要： | 目的：探讨肾缺血再灌注损伤时，小管上皮细胞ATP酶活性与自由基代谢的变化。方法：利用离体培养小管细胞的缺血再灌注模型，观察ATP酶与超氧化物歧化酶(superoxide dismutase，SOD)、脂质过氧化产物丙二醛(malondialdehyde，MDA)的变化。结果：缺血再灌注损伤导致肾小管细胞ATPase、SOD活性明显降低，而MDA含量明显增高，中药参麦注射液(ShenMai injeclion，SMI)能明显提高ATPase、SOD活性，同时脂质过氧化MDA含量明显降低。结论：实验结果提示在缺血再灌注中，氧自由基损伤了细胞的ATP酶和脂质成分，SMI对缺血再灌注损伤的肾小管上皮细胞有一定的保护作用。
|
| 关 键 词： | 肾缺血再灌注损伤 参麦注射液 肾小管细胞 ATP酶 自由基代谢 病理生理学 |
| 文章编号： | 1000-2669(2003)05-0393-02 |
EXPERIMENTAL STUDY ON CHANGES OF METABOLISM OF FREE RADICAL AND ATPase ACTIVITY INDUCED BY ISCHEMIA-REPERFUSION |
| |
| Huang Bo,et al. EXPERIMENTAL STUDY ON CHANGES OF METABOLISM OF FREE RADICAL AND ATPase ACTIVITY INDUCED BY ISCHEMIA-REPERFUSION[J]. Journal of Luzhou Medical College, 2003, 26(5): 393-394 |
| |
| Authors: | Huang Bo et al |
| |
| Affiliation: | Huang Bo,et al Department of Pathophysiology,Luzhou Modical College |
| |
| Abstract: | Objective:To investigate the changes of the metabolism of free radical and ATPase activity during ischemia-reperfusion. Methods: The content of the lipid peroxidation product--malondialdehyde(MDA), and the activity of superoxide dismutase(SOD) and ATPase were detected in cultured tubular cellular model of renal ischemia-reperfusion injury. Results: Ischemia and reperfusion reduced SOD and ATPase activity while MDA increased significantly; these changes became less conspicuous in those cells treated with SMI at the same time. Conclusion: The findings indicated that free radical play a crucial role in the injury to ATPase during the reperfusion of ischemic renal, which could be inhibited by SMI. |
| |
| Keywords: | ATPase Freeradical Renal Ischemic reperfusion ShenMai injection |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
