Increased urinary imidazolepropionic acid, N-acetylhistamine and other imidazole compounds in patients with intestinal disorders |
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| Authors: | C van der Heiden S K Wadman P K de Bree E A Wauters |
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| Affiliation: | 1. Department of Medical Research, China Medical University Hospital, Taichung 404, Taiwan;2. Department of Internal Medicine, Division of Nephrology, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chia-Yi City 600, Taiwan;3. Department of Nursing, Min-Hwei College of Health Care Management, Tainan City 736, Taiwan;4. Institute of Biochemistry, Microbiology and Immunology, Medical College, Chung Shan Medical University, Taichung 40201, Taiwan;5. Department of Medical Research, Chung Shan Medical University Hospital, Taichung 40201, Taiwan;6. Clinical Laboratory, Chung Shan Medical University Hospital, Taichung 40201, Taiwan;7. Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan;8. Division of Nephrology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung 40201, Taiwan |
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| Abstract: | In 26 out of a large group of patients with gastrointestinal disorders abnormal urinary imidazole excretion patterns were found. Most frequently excessive or increased amounts of imidazolepropionic acid (ImPA) occurred, and as next N-acetylhistamine was excreted in excess. In a number of cases the latter was accompanied by a substance identified as N-propionylhistamine. It is suggested that these excretory products are bacterial metabolites of histidine, if not absorbed in the intestinal lumen.All 26 patients excreted increased amounts of bacterial metabolites of tyrosine and/or phenylalanine as well: p-OH-phenylacetic and/or p-OH-benzoic acids and phenylacetic and/or benzoic acids respectively.Many patients showed increased urinary 4-amino-5-imidazolecarboxamide, its riboside and an unknown related compound X, especially in a later (recovery) phase when imidazolepropionic acid and N-acetylhistamine already decreased. It is thought that these metabolites are not of bacterial origin. |
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