抗心衰天然药物及活性化合物研究进展

心力衰竭(heart failure, HF)是世界性公众健康问题,全球心衰患者高达数千万人。其发病率每年递增,死亡率近年急剧上升,且有年轻化趋势,尽管近年来医学发展迅猛,但心衰的不良预后至今未得到有效改善。天然药物及其活性化合物具有温和低毒、多靶点综合疗效等特点,在恢复心脏功能、减轻能量障碍和提高生活质量等方面均具有明显优势。近年来在临床抗心衰应用中日益广泛,对天然药物及其活性化合物抗心衰机制进行深入研究,将为抗心力衰竭的临床治疗提供新的研究靶点和治疗方法。

Research progress of natural medicines and bioactive compounds against heart failure

Heart failure is a serious public health problem with tens of millions of people suffering from its poor prognosis.Epidemiological studies indicate that its morbidity is rising year by year and its mortality has dramatically increased in recent years,with a trend towards younger people.Although great progress has been achieved in the development of medicine in recent years,finding effective agents against heart failure remains an unconquered area in medicine development.A large number of natural medicines and their bioactive compounds,possessing mild and low toxicity as well as multiple target comprehensive effects,have been implicated in a wide range of pharmacological properties in recovering heart function,reducing energy barriers,and improving the life quality of patients.In recent years,they have been widely applied in clinical treatment for heart failure.Hence,summarizing and elucidating the convincing mechanisms for these natural medicines and their bioactive compounds would provide therapeutic targets and benefits for the treatment against heart failure.