| 复方盐酸曲马多人体药动学研究 |
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| 引用本文： | 赵永红,黄毅慧,黄仲义.复方盐酸曲马多人体药动学研究[J].中国药房,2007,18(20):1554-1555. |
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| 作者姓名： | 赵永红 黄毅慧 黄仲义 |
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| 作者单位： | 上海市静安区中心医院,上海市200040 |
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| 摘 要： | 目的:研究复方盐酸曲马多的人体药动学。方法:10名健康志愿者口服复方盐酸曲马多1片(每片含盐酸曲马多37.5mg,对乙酰氨基酚325mg),用高效液相色谱-荧光法测定血浆中曲马多的浓度,计算药动学参数。结果:口服复方盐酸曲马多片1片后AUC0~24为(1361.61±441.79)ng·h·mL-1,AUC0~∞为(1555.04±582.51)ng.·h·mL-1,Cmax为(134.81±33.96)ng·mL-1,tmax为(1.9±0.57)h,t1/2为(7.63±2.02)h。结论:本方法可用于复方盐酸曲马多人体药动学研究。
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| 关 键 词： | 高效液相色谱-荧光法 复方盐酸曲马多 药动学 |
| 文章编号： | 1001-0408（2007）20-1554-02 |
| 收稿时间： | 2007-01-20 |
| 修稿时间： | 2007-01-202007-06-01 |
Pharmacokinetics of Compound Tramadol Hydrochloride in Human Body |
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| ZHAO Yonghong,HUANG Yihui,HUANG Zhongyi.Pharmacokinetics of Compound Tramadol Hydrochloride in Human Body[J].China Pharmacy,2007,18(20):1554-1555. |
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| Authors: | ZHAO Yonghong HUANG Yihui HUANG Zhongyi |
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| Abstract: | OBJECTIVE:To study the pharmacokinetics of compound tramadol hydrochloride in human body.METHDOS:10 healthy volunteers were assigned to receive 1 tablet of compound tramadol hydrochloride (37.5mg tramadol hydrochloride and 325mg paracetamol),with serum concentration of tramadol determined by HPLC-fluorescence detection method.The pharmacokinetics were computed as well.RESULTS:The pharmacokinetics of compound tramadol hydrochloride determined after orally administration of 1 tablet of compound tramadol hydrochloride were as follows:AUC0～24=(1 361.61±441.79)ng·h·mL-1,AUC0～∞=(1 555.04±582.51)ng·h·mL-1,Cmax=(134.81±33.96)ng·mL-1,tmax=(1.9±0.57)h,and t1/2=(7.63±2.02)h.CONCLUSION:This above-mentioned method can be used to study the pharmacokinetics of compound tramadol hydrochloride in human body. |
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| Keywords: | HPLC-fluorescence detection method Compound tramadol hydrochloride Pharmacokinetics |
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