对146例新生儿出生后一周内部分免疫状态的初步研究

作者测定了出生后一周内的146例新生儿静脉血、60例脐血及其13例母血标本的IgG、IgM、IgA、CICCH_(50)和C_3的含量,发现出生后14小时内的新生儿静脉血IgG含量与脐血比较,差异无显著性(P>0.05),出生后14小时至 7天的新生儿,静脉血IgG含量比脐血低(P<0.01),提示脐血IgG只能代表出生后14小时内的新生儿的lgG水平,而不能代表生后14小时～7天新生儿IgG水平。除此,当新生儿IgM>20mg/dl、IgA>5 mg/dl时,应考虑有宫内感染存在。

PRELIMINARY STUDY ON THE PARTIAL IMMUNE STATE OF 146 NEONATES WITHIN 1 WEEK AFTER BIRTH

IgG, IgM, IgA, C_3, CH_(50) and CIC in146 neonates' venous blood were deter-mined within 1 week after birth and thesame were done in the cord blood of 60cases, and in 13 mothers' venous blood.The results revealed that there was no sig-nificant difference between the IgG levelsof venous blood of neonates within thefirst 14 hours and that of the cord blood(P>0.05), but the IgG levels of the cordblood were significantly higher than thatof the venous blood from 14 h to 7d (P< 0.01). This suggested that the IgG levelin the cord blood indicates only the IgGlevel in the venous blood of the neonateswithin the first 14 hours but not there-after. As IgM and IgA cannot pass throughthe placenta, when they appear higherthen 20mg/dl and 5 mg/dl respectively,intrauterine infection should be considered.Placenta is impermeable to complementand CIC. They are synthesized by the fetusitself and their amounts increase with thefetal age, and up to half of the amount ofadult at birth.