| 南五味子总木脂素软胶囊制备工艺优选 |
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| 引用本文： | 胡正芳,柳燕,李除夕,刘萌,丁菲,贾树田.南五味子总木脂素软胶囊制备工艺优选[J].中国实验方剂学杂志,2013,19(17):8-11. |
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| 作者姓名： | 胡正芳 柳燕 李除夕 刘萌 丁菲 贾树田 |
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| 作者单位： | 南京海陵中药制药工艺技术研究有限公司,南京,210049 |
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| 基金项目： | 南京市2010年第二批科技发展计划项目(201002018) |
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| 摘 要： | 目的:优选南五味子总木脂素软胶囊的制备工艺.方法:采用紫外分光光度法测定总木脂素含量.选择玉米油和聚乙二醇600(PEG600)为分散剂,氢化植物油和羧甲基纤维素钠(CMC-Na)为稳定剂,聚山梨酯80(Tween80)为助溶剂,筛选内容物最佳处方.以胶囊收率和轧囊现象为综合评价指标,通过正交试验考察进料口温度、胶囊出口温度和转篮干燥时间对制备工艺的影响.结果:内容物最佳处方为主药-玉米油-PEG600-1,2-丙二醇-CMC-Na-氢化植物油-Tween80-水(44∶10∶ 15∶ 1∶8∶9∶3∶ 10),最佳制备工艺为进料口温度50℃,胶囊出口温度20℃,转篮干燥时间24 h.结论:优选的制备工艺稳定可行.
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| 关 键 词： | 南五味子软胶囊 制备工艺 正交设计 总木脂素 |
| 收稿时间： | 4/3/2013 12:00:00 AM |
Optimization of Preparation Technology for Total Lignans from Schisandrae Sphenantherae Fructus Softcapsules |
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| HU Zheng-fang,LIU Yan,LI Chu-xi,LIU Meng,DING Fei and JIA Shu-tian.Optimization of Preparation Technology for Total Lignans from Schisandrae Sphenantherae Fructus Softcapsules[J].China Journal of Experimental Traditional Medical Formulae,2013,19(17):8-11. |
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| Authors: | HU Zheng-fang LIU Yan LI Chu-xi LIU Meng DING Fei and JIA Shu-tian |
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| Institution: | Nanjing Hailing Research and Development for Pharmaceutical Technology of Chinese Materia Medica Co. Ltd, Nanjing 210049, China;Nanjing Hailing Research and Development for Pharmaceutical Technology of Chinese Materia Medica Co. Ltd, Nanjing 210049, China;Nanjing Hailing Research and Development for Pharmaceutical Technology of Chinese Materia Medica Co. Ltd, Nanjing 210049, China;Nanjing Hailing Research and Development for Pharmaceutical Technology of Chinese Materia Medica Co. Ltd, Nanjing 210049, China;Nanjing Hailing Research and Development for Pharmaceutical Technology of Chinese Materia Medica Co. Ltd, Nanjing 210049, China;Nanjing Hailing Research and Development for Pharmaceutical Technology of Chinese Materia Medica Co. Ltd, Nanjing 210049, China |
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| Abstract: | |
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| Keywords: | Schisandrae Sphenantherae Fructus softcapsules preparation process orthogonal design total lignans |
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