| S—O2—1细菌核糖体制剂体外诱生白细胞介素的研究 |
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| 引用本文： | 刘碧崇,匡彦德.S—O2—1细菌核糖体制剂体外诱生白细胞介素的研究[J].中国抗生素杂志,1990,15(1):9-13. |
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| 作者姓名： | 刘碧崇 匡彦德 |
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| 作者单位： | 上海复旦大学生命科学院微生物系，上海复旦大学生命科学院微生物系，上海复旦大学生命科学院微生物系，上海医科大学基础部免疫教研室，上海医科大学基础部免疫教研室，上海医科大学基础部免疫教研室 上海 四川抗菌素工业研究所 成都，上海，上海，上海，上海，上海 |
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| 摘 要： | 用自制S-O_2-1细菌核糖体制剂,进行体外诱生白细胞介素1和2的研究。结果表明:S-O_2-1细菌核糖体制剂能诱导C_(57)BL/6小鼠的脾脏细胞分泌较低滴度的IL_2,腹腔粘附细胞分泌较高滴度的IL_1,其对IL_1的诱生效应高于同样实验条件下LPS(10μg/ml)的作用。
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| 关 键 词： | S－O2－1 细菌核糖体 白细胞介素 |
IN-VITRO STUDY OF INDUCING INTERLEUKINS BY S-O_2-1 RIBOSOMAL VACCINE |
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| Liu Bi-chon,Zhu Zhong-qiang and Li Jun-ying.IN-VITRO STUDY OF INDUCING INTERLEUKINS BY S-O_2-1 RIBOSOMAL VACCINE[J].Chinese Journal of Antibiotics,1990,15(1):9-13. |
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| Authors: | Liu Bi-chon Zhu Zhong-qiang and Li Jun-ying |
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| Abstract: | Previous experimental results in our laboratory showed that a nonpathogenic Gram-negative bacterial vaccine(S-O2-l) was a good macrophage stimulator with significant antitumor activity.
This paper reported the production of Interleukin 1 and 2 induced by ribosomal vaccine of S-O2-1 bacteria in-vitro.
We found that S-O2-1 ribosomal vaccine directly acted on spleen cells to produce Interle-ukin-2(IL2) and on peritoneal adherent cell to produce Interleukin-1(IL1). The productivity of IL1 was much more higher than that of IL2. |
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| Keywords: | S-O_2-1 Ribosomal vaccine Interleukin-2 Iaterleukin-1 |
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