Comparison of fructose and glucose ingestion before and during endurance cycling to exhaustion

BACKGROUND: Pre-exercise and exercise ingestion of fructose and glucose during cycling exercise were compared. METHODS: Experimental design: Seventeen trained subjects ingested a placebo prior to and during a cycling test to exhaustion at 75% VO2max (control group = CG). One week later, subjects were matched on exercise time to exhaustion (ETE) and assigned to a fructose group (FG) or a glucose group (GG). Subjects then performed a second cycling test to exhaustion, ingesting fructose or glucose doses. For all groups (CG, FG and GG), blood was drawn before and at timed intervals during exercise to determine glucose, lactate and free fatty acid (FFA) levels. RESULTS: The ETE for CG was less than either FG (p<0.02) or GG (p<0.001) but FG and GG were similar. FG and GG did not show any differences in blood lactate or blood FFA during the ETE. However, CG FFA levels were higher than those of FG (p<0.02) prior to exercise. CONCLUSIONS: This study demonstrated that fructose and glucose are of equal value in prolonging ETE in endurance cycling Ingesting fructose before and during exercise apparently provided a more constant supply of glucose to be available to the working muscles. The more stable blood glucose levels with fructose ingestion may be beneficial in reducing perceived exhaustion, and thereby allowing for an enhancement in exercise performance.