脑胶质瘤术后球囊法^32P内放疗联合替莫唑胺同步化疗的临床研究

目的：观察球囊法^32P内放疗同步替莫唑胺化疗对脑胶质瘤的临床疗效。方法：选取脑胶质瘤患者105例作为研究对象，随机分为两组，A组（52例）为球囊法^32P内放疗组，B组（53例）为行球囊法32P内放疗同步替莫唑胺化疗组。比较两组肿瘤体积缓解率及1、2和3年生存率，分析其疗效；比较两组治疗后KPS评分，分析其治疗不良反应。结果：A组患者治疗后完全缓解、部分缓解、好转、稳定和进展分剐为6、15、9、14和8例，B组分别为14、23、8、4和4侧；1、2和3年生存率分别为78．8％、57．7％、40．4％和92．4％、77．4％、60．4％；6个月、1和3年KPS评分分剐为75．89±9．23、71．97±10．73、64．31土10．11和85．22±9．40、83．96±10．33、81．97±11．01，经统计学分析组间差异均有统计学意义，P〈0．05。结论：球囊法^32P内放疗同步替莫唑胺化疗治疗脑胶质瘤优于单纯球囊法32P内放疗。

Balloon method ^32p radiotherapy combined with concurrent chemotherapy for Mo temozolomide treatment of postoperative cerebral glioma

OBJECTIVE： To study clinical efficacy of balloon 32 p internal radiotherapy with Mo temozolomide chemotherapy for brain glioma, and find out the more effective protocol for brain glioma. METHODS： Total 105 cases were randomly selected and divided into 2 groups. Group A （52 cases） was Balloon 32p Internal Radiotherapy only; Group B （53 cases） was Balloon method 32p internal radiotherapy and Mo temozolomide chemotherapy. Tumor volume response rate and 1,2,3 year survival rate of two groups were analyzed and KPS score was compared. The treatment side effects was analyzed. RESULTS： After treatment, complete remission, partial remission, better stability and progress in groups A were 6 cases,15 cases,9 cases,14 cases,8 cases, and in group B those were 14 cases,23 cases,8 cases,4 cases,4 cases;l, 2,3 year survival rates in group A and B were 78.8%,57.7%,40.4%and 92.4%,77.4%,60.4%; KPS score of 0.5,1, 3 years were 75.89±9.23,71.97±10.73,64.31±10. 11 and 85.22±9.40,83.96±10.33,81.97±11.01, There was a significant differences between the groups （P〈0.05）. CONCLUSION： Balloon method 32p internal radiotherapy for Mo temozolomide chemotherapy for glioma is better than simple balloon 32P internal radiotherapy.